Presentations:

Year 6

Avery BA, Boddu SP, Furr EB, Cutler SJ, McCurdy CR.  “Pharmacokinetics of Kratom Tea Extracts in Sprague Dawley Rates.”  Southeast Regional IDeA Meeting.  New Orleans, LA.  September 22-24, 2011. 

Dale OR, Ma G, Gemelli CA, Husni A, McCurdy C, Avery BA, Leon JF, Furr EB, Manly SP, Cutler SJ.  “Effects of Mitragynine and Its Derivatives on Human Opioid Receptors (Delta, Kappa, and Mu).”  UMMC Annual Neuroscience & Behavior Research Day.  Jackson, MS.  November 30, 2011.

Dale OR, Ma G, Gemelli CA, Husni A, McCurdy C, Avery BA, Leon JF, Furr EB, Manly SP, Cutler SJ.  “Effects of Mitragynine and Its Derivatives on Human Opioid Receptors (Delta, Kappa, and Mu).”  11th Annual Oxford International Conference on the Science of Botanicals (ICSB).  Oxford, MS.  April 16-19, 2012.

El-Alfy A, Wilson L, Furr EB, Song Y, Cutler SJ, Boddu SP, Avery BA, Boyer EW, McCurdy CR.  “Blockade of Opioid Withdrawal Syndrome by Orally Administered Lyophilized Kratom (Mitragyna speciosa) Tea and Mitragynine in Mice.”  Southeast Regional IDeA Meeting.  New Orleans, LA.  September 22-24, 2011.  (Oral Presentation & Poster)

Galal A, Radwan M, Ross S, Ahmed S, Slade D, Khan S, Gul W, ElSohly M.  “Bioactive Products from Singlet Oxygen Photooxygenation of Δ9-THC, Δ8-THC, and Δ9-THC-Acid-A.”  National Center for Natural Products Research Annual Poster Session.  University, MS.  October 14, 2011.

Gebril HM, Jekabsons MB.  “Manzamine A From The Marine Sponge Haliclona Stimulates Glucose Catabolism and Rescues Neurons From Apoptosis.”  National Center for Natural Products Research Annual Poster Session.  University, MS.  October 14, 2011.

Haron MH, Walker LA, Khan IA, Dasmahapatra AK.  “Asian Ginseng (Panax Ginseng) Prevents Ethanol-Induced Neurocranial Cartilage Deformities in a Fish Model of Fetal Alcohol Spectrum Disorder.”  National Center for Natural Products Research Annual Poster Session.  University, MS.  October 14, 2011.

Husni AS, Ross, SA, Radwan MM, Dale OR, Gemelli CA, Ma G, Manly SP, ElSohly MA, Cutler SJ.  “In Vitro Activity of Novel Cannabinoids from High Potency Cannabis sativa.”  National Center for Natural Products Research Annual Poster Session.  University, MS.  October 14, 2011.

Husni AS, Ross SA, Radwan MM, Dale OR, Gemilli CA, Ma G, Manly SP, ElSohly MA, Cutler SJ.  “Binding Affinity and Functional Activity of Novel Phytocannabinoids.” UMMC Annual Neuroscience & Behavior Research Day.  Jackson, MS.  November 30, 2011.

Jamalapuram S, Vuppala PK, Adbelazeem A, McCurdy CR, Avery BA.  “Determination of AZ66, a Metabolically Stable Sigma Receptor Ligand, in Rat Plasma by Ultra Performance Liquid Chromatography Mass Spectrometry and its Application to a Pharmacokinetic Study.”  2011 American Association of Pharmaceutical Scientists Annual Meeting.  Washington, DC.  October 23-27, 2011.

Jamalapuram S, Vuppala PK, Adbelazeem A, McCurdy CR, Avery BA.  “In Vitro Metabolic Stability and Pharmacokinetics in Lead Optimization of Novel Sigma Receptor Ligands.”  2011 American Association of Pharmaceutical Scientists Annual Meeting.  Washington, DC.  October 23-27, 2011.

Jamalapuram S, Vuppala PK, Mesangeau C, Bhat R, McCurdy CR, Avery BA.  “Rapid Identification of Metabolites of CM156 Using Tandem Mass Spectrometry.”  2011 American Association of Pharmaceutical Scientists Annual Meeting.  Washington, DC.  October 23-27, 2011.

Liu S, Patel RY, Daga PR, Liu H, Fu G, Doerksen R, Chen Y, Wilkins D.  “Multi-Class Joint Rule Extraction and Feature Selection for Biological Data.”  BIBM 2011 Conference.  Atlanta, GA.  November 12-15, 2011. (Oral Presentation & Published Proceedings)

Ma G, Kaplanciklia ZA, Dale OR, Tabanca N, Gemelli CA, Husni AS, Pasco DS, Cutler S, Manly SP.  “Identification of HZ Compounds as Cannabinoid Receptor Inverse Agonists.”    National Center for Natural Products Research Annual Poster Session.  University, MS.  October 14, 2011.

Ma G, Kaplanciklia ZA, Dale OR, Tabanca N, Gemelli CA, Husni AS, Pasco DS, Cutler S, Manly SP.  “Identification of HZ Compounds as Cannabinoid Receptor Inverse Agonists.”    UMMC Annual Neuroscience & Behavior Research Day.  Jackson, MS.  November 30, 2011.

Ma G, Kaplanciklia ZA, Dale OR, Altintop MD, Turan-Zitouni G, Tabanca N, Gemelli CA, Husni AS, Pasco DS, Cutler S, Manly SP.  “Identification of Hydrazone Derivatives as Cannabinoid Receptor Inverse Agonists.”  11th Annual Oxford International Conference on the Science of Botanicals (ICSB).  Oxford, MS.  April 16-19, 2012.

Mankus J, Wilson L, Murray D, Cutler S, McCurdy C.  “Effects of CB1 Antagonists, Inverse Agonist, and Agonist on Food Intake in Mice.”  UMMC Annual Neuroscience & Behavior Research Day.  Jackson, MS.  November 30, 2011.

Ross SA, Ahmed SA, Radwan MM, Slade D, ElSohly MA.  “Prenylated Dihydrostilbenes from High Potency Cannabis sativia.”  National Center for Natural Products Research Annual Poster Session.  University, MS.  October 14, 2011.

Vuppala PK, Jamalapuram S, Bhat R, Mesangeau C, McCurdy CR, Avery BA.  “Metabolism of CM304, a Novel Highly Selective Sigma-1 Receptor Antagonist With Potent Anti-Cocaine Actions, in Mouse, Rat and Human Liver Microsomes and Characterization of Metabolites by UPLC/MS/MS.”  2011 American Association of Pharmaceutical Scientists Annual Meeting.  Washington, DC.  October 23-27, 2011.

Vuppala PK, Jamalapuram S, Mesangeau C, McCurdy CR, Avery BA.  “Preclinical Characterization of CM304, a Novel and High Affinity Sigma-1 Receptor Ligand with Potent Anti-Cancer Actions.”  2011 American Association of Pharmaceutical Scientists Annual Meeting.  Washington, DC.  October 23-27, 2011.

Watson DE, Nolan TL, Mallela J, Wang J. McCurdy CR, Shariat-Madar Z.  “Comparative Modeling of Prolylcarboxypeptidase to Elucidate Factors Responsible For The Selective Hydrolysis of Kinins.”  PharmForum 2011. Memphis, TN.  May 16-17, 2011.

Wilson L, Mankus J, Beloate L, Murray D, Cutler S, McCurdy C.  “A Pharmacological Characterization of the Novel Compound AM630.”  UMMC Annual Neuroscience & Behavior Research Day.  Jackson, MS.  November 30, 2011.

Year 5

Adbelazeem AH, Mesangeau C, Jamalapuram S, Seminaro M, Avery BA, Matsumoto RR, McCurdy CR.  Optimization of CM156: A Metabolically Unstable, High-Affinity Sigma Receptor Ligand with Potent Anti-Cocaine and Anti-Methamphetamine Activity.  The F. Ivy Carroll Symposium. Durham, NC. November 1, 2010.

Beloate N, Townsend D, Wilson L, Rahim M, and El-Alfy AT.  Neurobehavioral Classification of Selective CB2 Agonist.  Annual UMMC Neuroscience & Behavior Research Day. Jackson, MS. December 1, 2010.

Chajkowski S, Shariat-Madar Z, Mellela J, Wang J, Rimoldi M. “Prolylcarboxypeptidase Catalyzed Conversion of Bradykinin to BK 1-8 and BK 1-7: LC-MS Kinetic Profiling and Analysis.” PharmForum 2010 Southern Regional Conference in Pharmaceutical Sciences. University, MS. May 24, 2010.

Coltharp M, Simpson B, Williams D, Day LB.  Schizandrin and Scopolamine Affect on Zebra Finch Spatial Learning.  Society for Neuroscience Annual Meeting. San Diego, CA. November 11-17, 2010.

Dale OR, Ma G, Gemelli CA, Husni AS, Pasco DS, Cutler SJ, Manly SP.  Evaluation of Natural Products as Specific Opiate Receptor Subtype Agonists/Antagonists.  2010 Neuroscience and Behavior Research Day. Jackson, MS. December 1, 2010.

Dale OR, Ma G, Gemelli CA, Husni AS, Pasco DS, Cutler SJ, Manly SP.  Identification of Specific Opiate Receptor Subtype Agonists/Antagonists from Natural Products.  National Center for Natural Products Research Annual Poster Session. University, MS. October 29, 2010.

Doerksen RJ. “Computational approaches to aid natural product discovery and development.” Department of Pharmacognosy, University of Mississippi. University, MS. Feb. 22, 2011. (Oral Presentation) 

Fu G, Liu S, Nan X, Chen Y, Wilkins DE, Doerksen RJ. “Implementation of Machine-Learning Algorithms for Identification and Development of Novel GSK-3β Inhibitors.” Mississippi NSF EPSCoR Annual Meeting. April 14, 2011. 

Fu G, Liu S, Nan X, Chen Y, Wilkins DE, Doerksen RJ. “Implementation of Machine-Learning Algorithms for Identification and Development of Novel GSK-3β Inhibitors.” University of Mississippi Graduate Student Council Poster Symposium & Research Day. University, MS. April 15, 2011. 

Gao J, Radwan MM, Leon F, Cutler SJ.  Benzyl derivatives from the fungus Aspergillus spp. with binding affinity for human opioid receptors and cannabinoid receptors.  37th Annual Medicinal Chemistry and Pharmacognosy Meeting-in-Miniature; MALTO. Oxford, MS. May 24, 2010.

Gole MS, Nagalla KT, Murray DB.  Effect of Hypertension on Myocardial Cannabinoid Receptor Expression.  Experimental Biology. Washington, DC. April 9-13, 2011. 

Gole M, Rahim M, El-Alfy A.  Interaction of 2-Arachidonoyl Glycerol with the Glutametergic System in Anxiety.  2010 Pharm Forum Regional Meeting. University, MS. May 23-25, 2010.

Haron MH, Walker L, Khan IA, Dasmahapatra AK.  Asian ginseng (Panax Ginseng) attenuates ethanol-induced neurocranial cartilage deformities in a fish model of fetal alcohol spectrum disorder. 10th Annual Oxford International Conference on the Science of Botanicals. Oxford, MS. April 2011.

Kevin DA, Patel RY, Doerksen RJ.  “Virtual screening evaluation of the MarinLit natural products database for cannabinoid receptor 2 (CB2) agonist-like features.” 241st ACS National Meeting & Exposition. Anaheim, CA. Division of Computers in Chemistry. March 2011. 

Kulkarni SJ, Pedduri Y, Chittiboyina AG, Avery MA.  Asymmetric Synthesis of Berkeleyamide A-Potent Caspase-1 Inhibitor.  AAPS Meeting. New Orleans, LA. November 2010. (Podium & Poster Presentation) – RECEIVED “Drug Design & Discovery sections Graduate Student Symposium Award”  

Liu S, Patel RY, Daga PR, Liu H, Fu G, Chen Y, Wilkins D, Doerksen R.  “Multi-Class Joint Rule Extraction and Feature Selection for Biological Data.” 8th Annual MidSouth Computational Biology and Bioinformatics Society Meeting. College Station, TX. AprIL 1-2, 2011. 

Liu S, Patel RY, Daga PR, Liu H, Fu G, Chen Y, Wilkins D, DoerksenRJ.  “Multi-Class Joint Rule Extraction and Feature Selection for Biological Data.” Mississippi NSF EPSCoR Annual Meeting.  April 14, 2011. 

Ma G, Dale OR, Gemelli CA, Husni AS, Pasco DS, Cutler SJ, Manly SP.  Establishment of Cannabinoid Receptor Binding and Functional Assays.  National Center for Natural Products Research Annual Poster Session. University, MS. October 29, 2010.

Ma G, Dale OR, Gemelli CA, Husni AS, Pasco DS, Cutler SJ, Manly SP.  Establishment of Cannabinoid Receptor Binding and Functional Assays.  2010 Neuroscience and Behavior Research Day. Jackson, MS. December 1, 2010.

Nan X, Fu G, Zhao Z,  Liu S, Patel RY, Liu H, Daga PR, Doerksen RJ, Dang X, Chen Y, Wilkins D.  “Leveraging Domain Information to Restructure Biological Prediction.”  Oral Presentation at 8th Annual MidSouth Computational Biology and Bioinformatics Society Meeting. College Station, TX. April 1-2, 2011. 

Patel RY, Doerksen RJ.  “Homology model based enrichment study of CB2 receptor agonists.” 37th Annual MALTO Medicinal Chemistry-Pharmacognosy Meeting. Oxford, MS. May 2010. 

Patel RY, Daga PR, Doerksen RJ.  “Predictive models of activity and selectivity for CB1 antagonists and CB2 agonists.” 2010 International Cannabinoid Research Society. Lund, Sweden. July 2010.

Rabey FM, Mallela J, Gadepalli RSVS, Diano S, Rimoldi JM, Shariat-Madar Z. “Inhibitors of the human prolylcarboxypeptidase”.  Annual Neuroscience and Behavior Research Day. Jackson, MS. December 1, 2010.

Radwan MM, Tabanca N, Wedge DE, Cutler SJ. Evaluation of the Antifungal Activities of Twenty Three Spices against Plant Pathogens. Presented at the 241st National Meeting of the American Chemical Society. Dallas, TX. March 27, 2011. (Oral Presentation)

Radwan MM, ElSohly MA, El-Alfy AT, Manly SP, Slade D, Ahmed SA, Seale S, Eslinger A, Wilson L, Dale O, Cutler S, Khan IA, Ross SA.  New Biologically Active Minor Cannabinoids from High Potency Cannabis Sativa.   The American Society of Pharmacognosy 51st Annual Meeting.  St. Petersburg, Fl. June 2010.

Radwan MM, ElSohly MA, El-Alfy AT, Manly SP, Slade D, Ahmed SA, Seale S, Eslinger A, Wilson L, Dale O, Cutler S, Khan IA, Ross SA.  New Biologically Active Minor Cannabinoids from High Potency Cannabis Sativa. 2010 Annual National Center for Natural Products Research Poster Session. University, MS. October 29, 2010.

Sammeta SM.  “Magnetophoresis:  A Novel Technique to Enhance Transdermal Drug Delivery.”  Pharm Forum 2010 Regional Meeting. Oxford, MS. May 23-25, 2010.  – (Podium Presentation) AWARDED “BEST PODIUM PRESENTATION AWARD”  

Sammeta SM, Repka MA, Murthy SN.  Transdermal Drug Delivery by Magnetophoresis in Combination with Chemical Permeation Enhancers.  AAPS Annual meeting and Exposition. New Orleans, LA. November 2010.

Simpson B, Coltharp M, El-Alfy A, Day LB.  Schizandrin Effects on Mice Treated with Scopolamine in the Morris Water Maze and Open Field Task.  Society for Neuroscience Annual Meeting. San Diego, CA. November 11-17, 2010.  

Tabanca N, Radwan M, Cutler SJ, Bernier UR, Becnel JJ, Wedge DE.  “Antifungal and Insecticide Activities of Twenty Three Spices”. 10th Annual Oxford International Conference on the Science of Botanicals (2011). Oxford, MS. April 2011.

Townsend D, Beloate N, Wilson L, Rahim M, El-Alfy A.  Anti-Obesity Potential of WG 4/27/1, A CB1 Receptor Antagonists.  Annual UMMC Neuroscience & Behavior Research Day. Jackson, MS. December 1, 2010.

Vaka SRK, Manda P, Repka MA, Murthy SN. Enhancement of brain uptake of intranasally administered brain derived neurotrophic factor using chitosan as barrier modulating agent. AAPS Annual meeting and Exposition. New Orleans, LA. November 2010.

Vaka SRK, Nagy T, Murthy SN.  Intranasal Formulation of Carnosic Acid for Upregulation of Neurotrophins in the Brain.  2010 Pharm Forum Regional Meeting. University, MS. May 23-25, 2010. (RECEIVED BEST POSTER AWARD) 

Vaka SRK, Nagy T, Murthy SN.  Intranasal Formulation of Carnosic Acid for Upregulation of Neurotrophins in the Brain.  National Center for Natural Products Research Annual Poster Session. University, MS. October 29, 2010. (RECEIVED 1st PLACE – GRADUATE STUDENT POSTER COMPETITION)

Vaka SRK, Nagy T, Murthy SN.  Intranasal Formulation of Carnosic Acid for Upregulation of Neurotrophins in the Brain.  American Association of Pharmaceutical Scientist Annual Meeting. New Orleans, LA. November 14-28, 2010.

Wang J, Kolte D, Shariat-Madar Z. “Factor XII promotes the growth of prostate cancer cells.” PharmForum 2010 Southern Regional Conference in Pharmaceutical Sciences. University, MS. May 24, 2010.

Wang X, Habib E, Leon F, Radwan M, Tabanca N, Gao J, Wedge DE, Cutler SJ.  Bioactivity directed isolation and characterization of antifungal compounds from Diospyros virginiana.  37th Annual Medicinal Chemistry and Pharmacognosy Meeting-in-Miniature; MALTO.  Oxford, MS. May 24, 2010.

Wang X, Habib E, Leon F, Radwan M, Tabanca N, Gao J, Wedge DE, Cutler SJ.  Bioactivity directed isolation and characterization of antifungal compounds from Diospyros virginiana. The American Society of Pharmacognosy 51st Annual Meeting.  St. Petersburg, FL. June 2010.

Wilson L, Hughes J, Ezell K, and El-Alfy AT.  Neurobehavioral Characterization of CB2 Ligands.  Pharm Forum 2010 Regional Meeting.  Oxford, MS.  May 23-25, 2010.

Wu M, Khan IA, Dasmahapatra AK.  Evaluation of Medaka as an Animal Model to Study Autism Spectrum Disorder.  10th Annual Oxford International Conference on the Science of Botanicals. Oxford, MS. April 2011.

Year 4

Ahmed SA, Ross SA, Slade D*, Radwan MM, Zulfiqar F, ElSohly MA. Cannabinoid Ester Constituents from High Potency Cannabis Sativa L. 7th Annual Oxford International Conference on the Science of Botanicals & American Society of Pharmacognosy. Oxford, MS. April 12-16, 2008.

Avery BA, Vinnikota H, Vuppala PK, Leon JF, Furr III EB, Adkins JE, Cutler SJ, McCurdy CR*. Pharmacokinetic and Tissue Distribution Studies of Mitragynine, a Naturally Occurring Opioid Agonist, in Rats using UPLC/MS/MS. 40th International Narcotics Research Conference (INRC). Portland, OR. July 12-16, 2009.

Battu S*, Majumdar S, Maddineni S, Chittiboyina AG, Repka MA. Characterization of Berberine Chloride-2-hydroxypropyl-β-cyclodextrin Complexes. 2009 Annual Meeting of the American Association of Pharmaceutical Scientists. Los Angeles, CA. November 8-12, 2009.

Battu S*, Maddineni S, Majumdar S, Gul W, ElSohly MA, Repka MA. Effect of Drug Load on Release Properties of Hot-Melt Extruded Formulations Containing a Delta-9-Tetrahydrocannabinol Dicarboxylic Acid Ester Prodrug. 2009 Annual Meeting of the American Association of Pharmaceutical Scientists. Los Angeles, CA. November 8-12, 2009.

Battu S*, Maddineni S, Majumdar S, Gul W, ElSohly MA, Repka MA. Influence of drug load on bioadhesive properties and stability of hot-melt extruded formulations containing a delta-9-tetrahydrocannabinol dicarboxylic acid ester prodrug. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Los Angeles, CA. November 2009.

Battu S*, Rahman Z, Majumdar S, Gul W, ElSohly MA, Repka MA. In vitro and In vivo Characterization of a Novel Amino Acid Ester Prodrug of Delta-9-Tetrahydrocannabinol, Delta-9-THC Valinate. 2009 Annual Meeting of the American Association of Pharmaceutical Scientists. Los Angeles, CA. November 8-12, 2009.

Battu S*, Rahman Z, Majumdar S, Gul W, ElSohly MA, Repka MA. In vitro and In vivo Characterization of a Novel Amino Acid Ester Prodrug of Delta-9-Tetrahydrocannabinol, Delta-9-THC Valinate. Annual Neuroscience and Behavior Research Day. The University of Mississippi School of Medicine. Jackson, MS. December 3, 2009.

Battu S*, Rahman Z, Majumdar S, Gul W, ElSohly MA, Repka MA, “Physico-Chemical characterization of a novel Δ9-tetrahydrocannabinol prodrug, Δ9-THC valinate”. SRDG PharmForum. University, MS. May 2009. (Podium Presentation)

Battu SK*, Majumdar S, Repka MA. Physicochemical characterization of Berberine chloride. National Center for Natural Products Research Annual Poster Session. University, MS. October 26, 2009.

Battu S*, Hingorani T, Rahman Z, Majumdar S, Gul W, ElSohly MA, Repka MA. Preformulation characterization of a novel delta-9-tetrahydrocannabinol-amino acid-dicarboxylic acid prodrug, delta-9-THC-Val-HS. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Los Angeles, CA. November 2009.

Battu S*, Rahman Z, Majumdar S, Gul W, ElSohly MA, Repka MA. Solubility and stability characteristics of novel amino acid ester prodrugs of delta-9-tetrahydrocannabinol: A comparative study based on polarity of the molecule. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Los Angeles, CA. November 8-12, 2009.

Dale OR*, Eslinger A, Prasanna S, Wahba AE, Hamann MT, Doerksen RJ, Cutler SJ, Manly SP. Development of the Invitrogen Z’‐Lyte™ kinase assay kit to screen natural products for GSK‐3beta inhibition. 50th Anniversary Meeting of the American Society of Pharmacognosy. Honolulu, HI. June 27- July 1, 2009.

Deng W, Maddineni S, Lu J, Hingorani T, Majumdar S, Repka MA, Formulation and in vitro evaluation of a sustained release system of Promethazine Hydrochloride using Eudragit® and Poly (Ethylene Oxide) blends. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Los Angeles, CA. November 2009.

Deng W, Lu J, Maddineni S, Hingorani T, Majumdar S, Repka MA. Influence of Eudragit® RS PO and processing conditions of hot-melt extrusion on drug stability and dissolution properties. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Los Angeles, CA. November 2009.

Deng W, Lu J, Maddineni S, Hingorani T, Majumdar S, Repka MA. Influence of plasticizers on the release of Promethazine HCl from hot-melt Eudragit® RS PO and Poly (Ethylene Oxide) polymeric matrix blends. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Los Angeles, CA. November 2009.

Doerksen RJ "Computational studies for rational design of GSK-3 and CDK5 inhibitors." 2nd Annual Meeting of the Mississippi Biophysical Consortium (MBC 2009). Mississippi State University. Starkville, MS. May 28-29, 2009. (Podium Presentation)

El-Alfy A, Wilson L, Furr III EB, Adkins JE, Leon JF, Cutler SJ, McCurdy CR*. Characterization of the Neurobehavioral Effects of Kratom (Mitragyna speciosa). 40th International Narcotics Research Conference (INRC). Portland, OR. July 12-16, 2009.

El-Alfy AT*, Wilson L, ElSohly MA, Abourashed EA. Neurobehavioral activities of nutmeg in the mouse tetrad assay. 50th Annual American Society of Pharmacognosy Meeting. Honolulu, HI. June 26 - July 1, 2009.

Eslinger A*, Dale O, Manly S, Cutler S, Radwan MM, Ahmed S, Slade D, ElSohly MA, Ross SA. Binding Affinities of constituents of Cannabis sativa on Human CB1 and CB2 Receptors. 50th Annual Meeting of the American Society of Pharmacognosy. Honolulu, HI. June 27- July 1, 2009.

Eslinger A*, Dale O, Cutler S and Manly S. Evaluation of Radioligand Binding with Cannabinoid Receptors 1 & 2. American Society of Pharmacognosy. Honolulu, HI. June 27th - July 1, 2009.

Eslinger A*, Dale O, Habib E, León JF, Manly S, Cutler SJ. Screening Non-sativa Natural Products on Human CB1 and CB2 Receptors. 50th Annual American Society of Pharmacognosy Meeting. Honolulu, HI. June 27 – July 1, 2009.

Ezell K*, Ross S, Ahmed S, Radwan M, Slade D, Khan I, ElSohly M, El-Alfy A. Evaluation of Delta-9-Tetrahydracannabinol and other Cannabinoids for antidepressant-like action in the automated mouse forced swim test. 50th Annual Meeting of the American Society of Pharmacognosy. Honolulu, HI. June 27 – July 1, 2009.

Ezell K*, Ross S, Ahmed S, Radwan M, Slade D, Khan I, ElSohly M, El-Alfy A. Evaluation of Delta-9-Tetrahydracannabinol and other Cannabinoids for antidepressant-like action in the automated mouse forced swim test. National Center for Natural Products Research Annual Poster Session. University, MS. October 23, 2009.

Gao J*, Radwan MM, Leon JF, Cutler SJ. Novel CB1 Inhibitors from the Fungus UK-143. 9th Annual Oxford International Conference on the Science of Botanicals. Oxford, MS. April 12, 2010.

Garripelli VK*, Jo S. Bioresponsive camptothecin delivery for brain cancer. National Center for National Products Research Annual Poster Session. University, MS. October 26, 2009.

Habib E*, Leon F, Adkins JE, Furr EB, McCurdy CR, Cutler, SJ. Chemical Characterization of Kratom (Mitragyna Speciosa). 50th Annual Meeting of the American Society of Pharmacognosy. Honolulu, HI. June 27- July 1, 2009.

Hammad MA*, Abdel-Bakky MS, Ashfaq MK, Walker LA. “The possible role of oxidized LDL and its receptor CXCL-16 in the pathogenesis of an inflammation-induced Monocortaline hepatotoxicity model” 49th Annual Meeting of the Society of Toxicology (SOT). Salt Lake City, UT. March 7–11, 2010. (Podium Presentation)

Hernandez C, Negrin G, Rubio S, Quintana J, Leon F, Cutler SJ, Estevez F. Evaluation of Synthetic Flavanoids on the Growth of Human Leukemia Cell Lines. XXXI Congress of the Spanish Society of Pharmacology. Seville, Spain. September 16-18, 2009.

Hingorani T, Srirangam R, Gul W, ElSohly M, Repka MA, Majumdar S*. Effect Topically Applied Delta-9-THC Microemulsion on Intraocular Pressure: A Preliminary Investigation. American Association of Pharmaceutical Scientists (AAPS) annual meeting. Los Angeles, CA. November 2009.

Hingorani T, Srirangam R, Majumdar S. Evaluation of Active and Passive Transport Systems in Corneas from Preserved Rabbit Eyes. American Association of Pharmaceutical Scientists (AAPS) annual meeting. Los Angeles, CA. November 2009.

Hingorani T, Deng W, Maddineni S, Lu J, Majumdar S, Repka MA. Thermal characterization and influence of Eudragit®--polyethylene oxide blends for modulating the release of a highly water soluble drug. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Los Angeles, CA. November 2009.

Kochanowska AJ, Marine organisms as a source of new antidepressant drug leads. 50th Annual American Society of Pharmacognosy Meeting. Honolulu, HI. June 26-July 1, 2009. (Podium Presentation)

Kolte DS*, Osman N, Yang J, Shariat-Madar Z. High molecular weight kininogen regulates endothelial function. 2010 Experimental Biology Meeting. Anaheim, CA. April 24-28, 2010.

Kolte SD*, Ngo M, Mahdi F, Shariat-Madar Z. Lipopolysaccharide upregulates the expression of prolylcarboxypeptidase in endothelial cells. 2009 Experimental Biology Meeting. New Orleans, LA. April 18-22, 2009.

Kulkarni SJ*, Pedduri Y, Chittiboyina AG, Avery MA. Synthesis of Berkeleyamide A-Potent Caspase-1 Inhibitor. 2010 National IDeA Symposium. Bethesda, MD. June 16-18, 2010.

Kulkarni SJ*, Pedduri Y, Chittiboyina AG, Avery, MA. Total synthesis of Berkeleyamide-A. 239th American Chemical Society National Meeting. San Francisco, CA. March 21-25, 2010.

Kulkarni SJ*, Pedduri Y, Chittiboyina AG, Avery MA. Towards Total Synthesis of Berkeleyamide A. National Center for Natural Products Research Annual Poster Session. University, MS. October 23, 2009.

Kulkarni SJ*, Pedduri Y, Chittiboyina AG, Avery MA. Towards Total Synthesis of Berkeleyamide A. 2009 Annual American Association of Pharmaceutical Scientists Meeting. Los Angeles, CA. November 8-12, 2009.

Lewellyn K*, Bialonska D, Roth BL, Zjawiony JK. Synthesis and Biological Evaluation of Marine Natural Product-Based Serotonin Receptor Ligands. 50th Annual American Society of Pharmacognosy Meeting. Honolulu, HI. June 27 – July 1, 2009.

Li J*, Jadhav AN, Khan I. Isolates from Brazilian Ginseng as Chemical Markers for Authentication of the Quality Control. 50th Annual Meeting of the American Society of Pharmacognosy. Honolulu, HI. June 27- July 1, 2009

Li J*, Jadhav AN, Khan IA. New Terpenoids from Pfaffia Paniculata Kuntze. 8th Annual Oxford International Conference on the Science of Botanicals. Oxford, MS. April 6-9, 2009.

Liu Y, Veena CK, Morgan JB, Mohammed KA, Jekabsons MB, Nagle DG, Zhou Y-D. Alpinumisoflavone, methylalpinumisoflavone, and rotenone – Small molecule Loncocarpus glabrescens metabolites that inhibit HIF-1 activation, tumor angiogenesis, and tumor cell migration by acting through by multiple mechanisms. American Association for Cancer Research 100th Annual Meeting. Denver, CO. April 18-22, 2009.

Lu J, Deng W, Maddineni S, Hingorani T, Jo S, Majumdar S, Repka MA. Influence of Eudragit RS PO and PEO Blends on the Bio-adhesive and Mechanical Properties of Hot melt Extruded Films, American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Los Angeles, CA. November 2009.

Maddineni S, Battu S, Kolter K, Langley NA, Repka MA. Effect of processing conditions on stability and drug release from Nifedipine--Kollidon® VA 64 hot-melt extrudates, American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Los Angeles, CA. November 2009.

Maddineni S, Battu S, Kolter K, Langley NA, Repka MA. Influence of processing aids and process parameters on post-processing content of Nifedipine--Kollidon® VA 64 hot-melt extrudates. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Los Angeles, CA. November 2009.

Majumdar S*, Srirangam R. Vitreal pharmacokinetics of hesperidin following intravitreal administration. Association for Research in Vision and Ophthalmology meeting, Fort Lauderdale, FL. May 3-7, 2009.

Mallela J and Shariat-Madar Z*. Dynorphin A regulates inflammation and angiogenesis by controlling the plasma kallikrein-kinin system. 2010 National IDeA symposium. Bethesda, MD. June 16-18, 2010.

Mallela J*, Yang J, Shariat-Madar Z. Dynorphin regulates the plasma kallikrein-kinin system function on astrocytes. 2009 International Society on Thrombosis & Haemostasis Meeting. Boston, MA. July 11-16,2009. PP-MO-885.

McCurdy CR. Characterization of the opioid withdrawal effects of Mitragyna speciosa, 7th International Congress of Pharmaceutical Sciences (CIFARP). Centro de Convencoes Ribeirão Preto SP Brazil. September 6-9, 2009. (Podium Presentation)

McCurdy CR*, Habib E, Leon JF, Adkins JE, Furr III EB, Polgar WE, Toll L, Cutler SJ. Chemical and Pharmacological Characterization of Kratom (Mitragyna speciosa). 40th International Narcotics Research Conference (INRC). Portland, OR. July 12-16, 2009.

Mohammed N, Singh A, Patwardhan K, Repka MA. Efficacy of twin-screw hot-melt extrusion processing over hot-melt casting methods for formulating transmucosal films with polymer blends. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Los Angeles, CA. November 2009.

Mohammed N, Singh A, Patwardhan K, Repka MA, Influence of Klucel® and Eudragit® blends on the release of a water soluble model drug in hot-melt extrudates, American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Los Angeles, CA. November 2009.

Mohammed N, Rahman Z, Gul W, Majumdar S, ElSohly MA, Repka MA. Lipophilicity characterization of various prodrugs of delta-9-tetrahydrocannabinol (THC) using a reverse phase HPLC method and its comparison with software generated values. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Los Angeles, CA. November 2009.

Morgan JB, “Kalkitoxin inhibits angiogenesis, disrupts cellular hypoxic signaling, and blocks mitochondrial electron transport in tumor cells.” 50th Annual Meeting of the American Society of Pharmacognosy. Honolulu, HI. June 27 – July 1, 2009. (Podium Presentation)

Morgan JB*, Jekabsons MB, Agarwal AK, Zhou Y-D, Nagle DG. The antifungal alkaloid sampangine uncouples mitochondrial electron transport. 50th Annual Meeting of the American Society of Pharmacognosy. Honolulu, HI. June 27 - July 1, 2009.

Patel RY, Doerksen RJ. “Affinity and selectivity of indirubin analogues for GSK-3β and CDK5: A molecular dynamics simulation study.” 36th Annual MALTO Medicinal Chemistry-Pharmacognosy Meeting. Memphis, TN. May 2009.

Patwardhan K, Kolter K, Langley NA, Repka MA. Influence of Kollidon® VA 64 on the release profiles of Carbamazepine from hot-melt extruded films. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Los Angeles, CA. November 2009.

Patwardhan K, Singh A, Mohammed N, Repka MA. Investigation of Eudragit® EPO as a release modifier utilizing hot-melt extrusion for novel drug delivery systems: Effect of pH modifiers. American Association of Pharmaceutical Scientists Annual Meeting and Exposition, Los Angeles, CA, November 2009.

Radwan MM*, ElSohly MA, Slade D, Ahmed SA, Khan IK, Ross SA. Biologically Active Cannabinoids from high potency Cannabis sativa. 50th Annual Meeting of the American Society of Pharmacognosy, Honolulu, HI, June 27- July 1, 2009.

Repka M, “Hot-Melt Extrusion: A Novel Oral Solids Processing Technology”, AAPS Annual Meeting and Exposition, Full Symposium Organizer and Speaker, Los Angeles, CA, November 12, 2009. (Podium Presentation)

Repka M, “Hot-Melt Extrusion of Polymer Blends and Sensitive Actives”, Workshop, Amgen, Thousand Oaks, CA, June 4-5, 2009. (Podium Presentation)

Repka M, “Hot-Melt Extrusion: Use of Polymer Blends for Pharmaceutical Applications”, 1st International Symposium for Industrial Pharmacy and Clinical Pharmacy, Guangzhou, China, October 9-11, 2009. (Podium Presentation)

Repka M, “Melt Extruded Drug Delivery Systems via Polymer Blends”, Pharmacy Lecture Seminar Series, The University of Wisconsin at Madison, September 17, 2009. (Podium Presentation)

Repka M, “Stabilization of actives in hot-melt extruded PEO films, APV Experts Workshop on Hot-Melt Extrusion and its use in the manufacturing of pharmaceutical dosage forms”, Ludwigshafen, Germany, December 1-2, 2009. (Podium Presentation)

Ross SA*, Radwan MM, Ahmed S, Slade D, Eslinger A, Dale O, Manly S, Cutler S, ElSohly MA. Binding Affinities of constituents of Cannabis sativa on Human CB1 and CB2 Receptors. The International Cannabinoid Research Society Symposium. St. Charles, IL. July 7-11, 2009.

Ross SA*, Radwan MM, Ahmed S, Slade D, Eslinger A, Dale O, Manly S, Cutler S, ElSohly MA. Cannabis: Old Plant, New constituents, and potential therapeutic agents. The Southeast IDeA Regional Meeting, Charleston, SC, November 9-11, 2009.

Sammeta SM, Murthy SN*. Transdermal drug delivery by Magnetophoresis in combination with chemical permeation enhancers, The 37th Annual meeting and exposition of the controlled release society, Portland, Oregon, USA, July 10-14, 2010

Seale S*, Smillie T, Wang YH, Khan I, El-Alfy A. Interactions of Gingko biloba and green tea with acrylamide-induced neurotoxicity. 50th Annual American Society of Pharmacognosy Meeting, Honolulu, HI, June 26 - July 1, 2009.

Seale S*, Smillie T, Wang YH, Khan I, El-Alfy A. Interactions of Gingko biloba and green tea with acrylamide-induced neurotoxicity. National Center for Natural Products Research Annual Poster Session, University, MS, October 23, 2009.

Shah F*, Wu Y, Golbraikh A, Wu T, Wang XS, Fourches D, Tropsha A., Avery M.A. Development of binary QSAR models to predict the biological activity of semi-synthetic artemisinin derivatives by kNN and SVM approach. 239th American Chemical Society at San Francisco, CA, March 21-25, 2010.

Shariat-Madar Z*, Ngo M, Kolte D, Mahdi F. Molecular signaling pathway regulating prolylcarboxypeptise-dependent kinin generating cascade in inflammation. 2009 International Society on Thrombosis & Haemostasis Meeting, Boston, MA, July 11-16, 2009. PP-TH-133.

Simpson B*, Tramel B, Day LB. Comparison of Spatial Learning in CD1 and C57 Mice Strains Using the Morris Water Maze. Association of Southeastern Biologist Annual Meeting, Asheville, NC, April 7-10, 2010.

Singh A, Patwardhan K, Mohammed N, Repka MA*. Development of transmucosal drug delivery system containing polyethylene oxide and Eudragit® EPO as a release modifier utilizing hot-melt extrusion techniques: Effect of levels of release modifying polymer and plasticizers, American Association of Pharmaceutical Scientists Annual Meeting and Exposition, Los Angeles, CA, November 2009.

Singh A, Patwardhan K, Mohammed N, Repka MA. Mechanical properties and moisture content of polymer blends as a function of plasticizer concentration formulated using hot-melt extrusion. American Association of Pharmaceutical Scientists Annual Meeting and Exposition, Los Angeles, CA, November 2009.

Singh A, Patwardhan K, Mohammed N, Stodghill SP, Repka MA. Preformulation studies for hot-melt extrusion of selected polymers using thermal analysis and FTIR spectroscopy, American Association of Pharmaceutical Scientists Annual Meeting and Exposition, Los Angeles, CA, November 2009.

Sivaprakasam P, Tosso PN, Doerksen RJ. Structure-activity relationship and comparative docking studies for cycloguanil analogs as PfDHFR-TS inhibitors. 2009 American Association of Colleges of Pharmacy (AACP) Annual Meeting and Seminars in Boston, MA, July 18-22, 2009.

Srirangam R*, Hippalgoankar, Majumdar S. Dose dependant vitreal pharmacokinetics of hesperidin following intravitreal administration. American Association of Pharmaceutical Scientists (AAPS) meeting, Los Angeles, CA, November 2009.

Srirangam R “Ocular Deliv;ery of Hesperidin and its Aglycone Hesperetin for the Treatment of Posterior Segment Diseases.” 2009 Pharmforum, University of Mississippi, May 20, 2009. (Podium Presentation)

Srirangam R* and Majumdar S. Ocular tissue concentrations of Hesperidin following topical and intravenous administration. American Association of Pharmaceutical Scientists (AAPS) meeting, Los Angeles, CA, November 2009.

Srirangam R and Majumdar S. Physicochemical properties and transscleral permeability of Hesperetin. American Association of Pharmaceutical Scientists (AAPS) meeting, Los Angeles, CA, November 2009.

Srirangam R and Majumdar S. Transcorneal permeability characteristics of Hesperetin. American Association of Pharmaceutical Scientists (AAPS) meeting, Los Angeles, CA, November 2009.

Thumma S, Deng W*, Majumdar S, ElSohly MA, Gul W, Repka MA. Influence of Plasticizers on the Release of a delta-9-Tetrahydrocannabinol Prodrug Incorporated in Poly (Ethylene Oxide) Matrices. National Center for Natural Products Research Annual Poster Session, University, MS, October 26, 2009.

Upadhye SB*, Majumdar S, Gul W, ElSohly M, Repka MA. Dissolution behavior of solid dispersions of a delta-9-tetrahydrocannabinol prodrug and modified cyclodextrins. 2009 Annual Meeting of the American Association of Pharmaceutical Scientists, Los Angeles, CA, November 8-12, 2009.

Upadhye SB*, Majumdar S, Gul W, ElSohly M, Repka MA. Influence of modified cyclodextrins on the mechanical properties and bioadhesion of hot-melt extruded polyethylene oxide transmucosal films containing a delta-9-tetrahydrocannabinol prodrug, 2009 Annual Meeting of the American Association of Pharmaceutical Scientists, Los Angeles, CA, November 8-12, 2009.

Upadhye SB*, Majumdar S, Gul W, ElSohly M, Repka MA. Influence of modified cyclodextrins on the mechanical properties and bioadhesion of hot-melt extruded polyethylene oxide transmucosal films containing a delta-9-tetrahydrocannabinol prodrug, Annual Neuroscience and Behavior Research Day, The University of Mississippi School of Medicine, Jackson, MS, December 3, 2009.

Upadhye SB*, Majumdar S, Gul W, ElSohly MA, Repka MA. “Preparation and characterization of an inclusion complex of hemisuccinate ester prodrug of Δ9-tetrahydrocannabinol with modified beta-cyclodextrins”, SRDG-PharmForum, University, MS, May 2009. (Podium Presentation)

Upadhye SB*, Majumdar S, Gul W, ElSohly MA, RepkaMA. The influence of inclusion complex Formation with cyclodextrins on thermal stability and permeation of hemisuccinate prodrug of delta-9- Tetrahydrocannabinol. National Center for Natural Products Research Annual Poster session, University, MS, October 26, 2009.

Veena CK, Liu Y, Mao SC, Morgan JB, Mahdi F, Jekabsons M, Zhou YD*, Nagle DG. Inhibition of hypoxia-inducible factor-1 activation constitutes a novel mechanism of action for the alternative anticancer medicine Paw Paw and its active ingredient acetogenins. American Association for Cancer Research - 100th Annual Meeting, Denver, Colorado, April 18-22, 2009.

Wilson L, Chen C*, Mullen A*, Smillie T, Khan I, El-Alfy A. Characterization of Neurobehavioral Actions of California poppy Extract. 2010 National IDeA Symposium, Bethesda, Maryland, June 16-18, 2010.

Wilson L, Hughes J, Mullen A*, Chen C*, El-Alfy A. Neurobehavioral Characterization of GP1a, a Selective CB2 Ligand. 2010 National IDeA Symposium, Bethesda, Maryland, June 16-18, 2010.

Wilson L*, Ross S, Seale S, Radwan M, Ahmed S, Slade D, Khan I, ElSohly M, El-Alfy A. Pharmacological characterization of minor cannabinoid constituents in the mouse tetrad assay. 50th Annual American Society of Pharmacognosy Meeting, Honolulu, HI, June 26 – July 1, 2009.

Zhou Y-D. “Inhibition of hypoxia-inducible factor-1 activation: A novel mechanism of action for the alternative medicine paw paw and its active annonaceous acetogenin constituents.” 50th Annual Meeting of the American Society of Pharmacognosy, Honolulu, HI, June 27 – July 1, 2009. (Podium Presentation)

Year 3

Agnihotri VK, ElSohly HN, Khan SI, *Smillie TJ, *Khan IA, Walker LA. Constituents of Leonotis leonurus Flowering Tops. 7th Oxford International Conference on the Science of Botanicals (ICSB). University, MS. April 12th - 16th 2008.

Agnihotri VK, ElSohly HN, Khan SI, *Smillie TJ, *Khan IA, Walker LA. Constituents of Nymphaea caerulea Flowers and their Antioxidant Activity. 7th Oxford International Conference on the Science of Botanicals (ICSB). University, MS. April 12th -16th 2008.

Agnihotri VK, ElSohly HN, *Smillie TJ, *Khan IA, Walker LA. New Labdane Diterpenes from Leonurus cardiac. 7th Oxford International Conference on the Science of Botanicals (ICSB).  University, MS. April 12th -16th 2008.

Ahmed, S, *Ross SA, *Slade D, Radwan M, *Khan I, ElSohly M. Minor oxygenated cannabinoids from high potency Cannabis sativa L. Phytochemical Society of North America (PSNA) annual meeting. Pullman, Washington. June 25-30, 2008.

Ahmed, S, *Ross SA, *Slade D, Radwan M, *Khan I, ElSohly M. Minor oxygenated cannabinoids from high potency Cannabis sativa L. National Center for Natural Products Research Annual Poster Session. University, MS. October 31, 2008.

*Battu S, Rahman Z, *Majumdar S, Gul W, ElSohly MA, *Repka MA. Effect of pH and 2-hydroxypropyl-beta-cyclodextrin on solubility of delta-9-tetrahydrocannabinol and two novel pro-drugs, ELI-UN1-88-4 and ELI-UN1-89-2. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Atlanta, GA. November 2008.

*Battu S, Rahman Z, *Majumdar S, W. Gul W, ElSohly MA, *Repka MA. Evaluation of a novel delta-9 tetrahydrocannabinol prodrug, ELI-UNI-88-4. Annual Neuroscience and Behavior Research Day. Jackson, MS. December 3, 2008.

*Battu S, *Majumdar S, *Repka MA. Evaluation of physicochemical properties of berberine chloride. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Atlanta, GA. November 2008.

*Battu S, Mohammed N, *Repka MA. Influence of drug load and powder flow properties on content uniformity of actives prior to, during and after hot-melt extrusion. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Atlanta, GA.  November 2008.

*Battu S, Mohammed N, Deng W, *Repka MA. Influence of extruder type on content uniformity and effect of a processing aid on drug release of hot-melt extruded polyethylene oxide films. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Atlanta, GA. November 2008.

*Battu S, Rahman Z, *Majumdar S, Gul W, ElSohly MA, *Repka MA. Preformulation studies of a novel delta-9 tetrahydrocannabinol prodrug. National Center for Natural Products Research Annual Poster Session. October 31, 2008. University, MS.

*Bowling JJ, Salmeto AL, Hymel KA, Sufka KJ, *Hamann MT. In Vivo Functional Studies of the Anxiolytic Marine Natural Product Aaptamine in Domestic Fowl Chicks. Neuroscience and Behavior Research Day. Jackson, MS. December 3, 2008.

Cui J, Leon JF, Mesangeau C, Peres B, *Adkins JE, *Furr EB, Arribas M, Nolan TL, Cutler SJ, Polgar WE, Toll L, *McCurdy CR. Studies on the determination of the pharmacophoric elements of the naturally occurring opioid receptor agonist, mitragynine and related alkaloids from Mitragyna speciosa. College on Problems of Drug Dependence 70th Annual Scientific Meeting, San Juan, Puerto Rico. (June 14-19, 2008).

*Daga PR, *Prasanna S, Peng J, Place A, *Hamann MT, *Doerksen RJ. Computational efforts to predict absolute configuration and protein-ligand interactions of marine natural products. Gordon Research Conference: Oceans and Human Health. Tilton, NH. June 2008.

*Daga PR, Odde S, *Hamann MT, *Doerksen RJ. Free Energy Calculations on the Binding of Natural Latrunculins and Semi-synthetic Derivatives to G-Actin. 8th Annual Oxford International Conference on the Science of Botanicals & American Society of Pharmacognosy 4th Interim Meeting. Oxford, MS. April 6-9, 2009. **Received Certificate for Honorable Mention, Graduate Student Poster Competition.

*Daga PR, Odde S, *Hamann MT, *Doerksen RJ. Molecular dynamics and free energy calculations explain decreased inhibition of G-actin by oxalatrunculin B and semi-synthetic analogs of latrunculin B. 237th American Chemical Society National Meeting. Salt Lake City, UT. March 24, 2009.

Deng W, Singh A, *Battu SK, Mohammed NN, Jo S, *Repka MA. Bioadhesive Properties of Hot-Melt Extruded Films Containing Lidocaine HCl, Metformin HCl and Prochlorperazine Maleate. American Association of Pharmaceutical Scientists. Atlanta, GA. November 16-19, 2008.

*El-Alfy A, *Wilson L, ElSohly M, Abourashed E. Characterization of neurobehavioral effects of nutmeg extracts in the mouse tetrad assay. National Center for Natural Products Research Annual Poster Session. University, MS. October 31, 2008.

*El-Alfy A, *Wilson L, ElSohly M, Abourashed E. Characterization of neurobehavioral effects of nutmeg extracts in the mouse tetrad assay. Neuroscience and Behavior Research Day.  The University of Mississippi Medical Center. Jackson, Mississippi. December 3, 2008.

*El-Alfy A, *Wilson L, *Childress S, *Radwan M, Ahmed S, *Slade D, *Khan I, ElSohly M, *Ross S. Pharmacological characterization of minor cannabinoid constituents in the mouse tetrad assay. National Center for Natural Products Research Annual Poster Session.  University, MS October 31, 2008.

*El-Alfy A, *Wilson L, *Childress S, *Radwan M, Ahmed S, *Slade D, *Khan I, ElSohly M, *Ross S. Pharmacological characterization of minor cannabinoid constituents in the mouse tetrad assay. Neuroscience and Behavior Research Day. Jackson, MS. December 3, 2008.

*El-Alfy A, Abourashed E, *Ivey K, *Wilson L, *Childress S, ElSohly M, Matsumoto R. Towards a Better Understanding of the Psychopharmacology of Nutmeg – Observed Activities in the Mouse Tetrad Assay. National IDeA Meeting. August 6-8, 2008.  Washington, DC.

*Ganesan S, Tripathi LM, Llias M, *Khan IA, Walker LA, Tekwani BL. Evaluation of in vitro inhibition of human monoamine oxidases (MAOs) by natural product extracts and flavonoids.  National Center for Natural Products Research Annual Poster Session. University, MS.  October 31, 2008.

Gul W, *Repka MA. Influence of plasticizers on the release of a delta-9-tetrahydrocannabinol prodrug incorporated in poly (ethylene oxide) matrices. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Atlanta, GA. November 2008.

Gul W, Carvalho P, *Radwan MM, *Ross SA, Ahmed SA, *Slade D, Avery M, *Khan IA, ElSohly MA. X-ray crystal stuctures of alpha and beta cannabispiranol isolated from Cannabis sativa L. National Center for Natural Products Research Annual Poster Session. October 31, 2008. University, MS.

Hingorani T, *Srirangam R, Jain R, *Majumdar S. A Comparison of Passive and Active Transport Characteristics across Freshly Excised versus Preserved Rabbit Corneas. Annual Neuroscience and Behavior Research Day. Jackson, MS. December 3, 2008.

Hingorani T, *Srirangam R, *Majumdar S. Transcorneal Permeation of L- and D- Aspartate Acyclovir Prodrugs: Delineation of Passive Diffusion versus Transporter Involvement.  American Association of Pharmaceutical Scientists Annual Meeting. November 2008.  Atlanta, GA.

Hingorani T, *Srirangam R, *Majumdar S. Viability of One-Day Old Rabbit Tissues For In-Vitro Permeability Studies. National Center for Natural Products Annual Poster Presentation. October 31, 2008. University MS.

Hingorani T, *Srirangam R, Jain R, *Majumdar S. Viability of one-day old rabbit ocular tissues, for in vitro permeation studies. American Association of Pharmaceutical Scientists Annual Meeting. November 2008. Atlanta, GA.

*Hippalgaonkar K, Gul W, Elsohly M, *Repka MA, *Majumdar S. Complexation of delta-8-tetrahydrocannabinol with cyclodextrin’s: Effect on aqueous solubility, stability and in vitro cornieal permeability. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Atlanta, GA. November 2008.

*Hippalgaonkar K, Gul W, ElSohly, MA, *Repka MA, *Majumdar S. Effect of Surfactants and Cyclodextrins on Aqueous Solubility and Stability of Delta-8-Tetrahydrocannabinol. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Atlanta, GA.  November 2008.

*Hu Y, Willett KL, *Khan IA, Scheffler BE, Dasmahapatra AK. Epigenetic Analysis of Aldh1A2 Gene in Japanese Medaka Developmentally Exposed to Ethanol. Annual Meeting South Central Chapter of the Society of Toxicology. Little Rock, AR. September, 2008.

*Hu Y, Willett KL, *Khan IA, Scheffler BE, Dasmahapatra AK. Epigenetic Analysis of Aldh1A2 Gene in Japanese Medaka Developmentally Exposed to Ethanol. National Center for Natural Products Research Annual Poster Session. University, MS. October 31, 2008.

*Hu Y, Willett KL, *Khan IA, Dasmahapatra AK. Promoter Analysis of Aldh1A2 Gene of Japanese Medaka Developmentally Exposed to Ethanol. Sigma-Xi Student Research Poster Session. April, 2008. Oxford, MS.

*Ivey K, *Robinson K, *Ross S, Ahmed S, *Radwan M, *Slade D, *Khan I, ElSohly M, *El-Alfy A. Evaluation of delta-9-tetrahydrocannabinol and other cannabinoids for antidepressant-like action in the automated mouse forced swim test. National Center for Natural Products Research Annual Poster Session. University, MS. October 31, 2008.

*Ivey K, *Robinson K, *Ross S, Ahmed S, *Radwan M, *Slade D, *Khan I, ElSohly M, *El-Alfy A. Evaluation of delta-9-tetrahydrocannabinol and other cannabinoids for antidepressant-like action in the automated mouse forced swim test. Neuroscience and Behavior Research Day.  Jackson, MS. December 3, 2008.

*Kochanowska AJ, *El-Alfy A, *Ivey K, Sufka K, *Hamann MT. Antidepressant and sedative indole alkaloids isolated from marine sponges. Neuroscience and Behavior Research Day.  Jackson, MS. December 3, 2008.

*Kochanowska AJ, *Childress S, *El-Alfy A, Matsumoto RR, Stewart G, Sufka K, *Hamann MT. Antidepressant secondary metabolites from three Florida sponges. 7th Annual Oxford International Conference on the Science of Botanicals & American Society of Pharmacognosy 4th Interim Meeting. Oxford, MS. April 12-16, 2008.

*Mallela J, *Perkins R, Yang J, Pedigo S, Rimoldi JM, *Shariat-Madar Z. Functional importance of the N-terminal region of human prolylcarboxypeptidase. Gordon Research Conference: Oceans & Human Health. Tilton, NH. June 2008

*Mallela J, *Perkins R, Yang J, Pedigo S, Rimoldi JM, *Shariat-Madar Z. Functional importance of the N-terminal region of human prolylcarboxypeptidase. Jackson Cardiovascular-renal Meeting Oct. 15-18, 2008.

*McCurdy CR. Mitragyna speciosa. 4th Interim American Society of Pharmacognosy Meeting. Oxford, MS. April 12-16, 2008. Oral Presentation.

Mohammed NN, Rahman Z, *Repka MA. Clotrimazole 2-Hydroxy Propyl Beta Cyclodextrin Complex for Vaginal Delivery. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Atlanta, GA. November 2008.

Nagle DG, *Zhou YD, Liu Y, *Morgan JB, Veena CK, Liu R, Jekabsons MB, Mohammed KA, Mao S-C, El Sayed KA. Discovery of Marine Natural Products that Target Tumor Hypoxia.  Phytochemical Society of Europe Symposium on Natural Products in Cancer Therapy.  Naples, Italy. September 23 - 26, 2008. Oral Presentation - Invited Plenary Speaker (DGN).

Nagle DG, *Datta S, *Morgan JB, Liu Y, Jecabsons MB, Liu R, Mohammed KA, Dai J, Veena CK, *Jia H, *Zhou YD. The Need for Alternative Separation Methods in Molecular-Targeted Drug Discovery. 6th International Symposium on Chromatography of Natural Products.  Lublin, Poland. June 15 - 18, 2008. Oral Presentation - Invited Plenary Speaker (DGN)

*Radwan M, *Ross SA, *Slade D, Ahmed S, ElSohly, M. Isolation and Characterization of New Cannabis Constituents from a High Potency Variety. 7th Annual Oxford International Conference on the Science of Botanicals and American Society of Pharmacognosy. Oxford, MS. April 12-16, 2008.

*Radwan M, ElSohly M, *Slade D, Ahmed S, *Khan I, *Ross SA. New bioactive matabolites from high potency Cannabis sativa L. Phytochemical Society of North America (PSNA) annual meeting. Pullman, Washington. June25-30, 2008.

*Radwan MM, ElSohly MA, *Slade D, Ahmed AS, *Khan IA, *Ross SA. New Bioactive Metabolites from High Potency Cannabis Sativa L. National Center for Natural Products Research Annual Poster Session. University, MS. October 31, 2008.

*Radwan MM, ElSohly MA, *Slade D, Ahmed SA, *Wilson L, *Al-Alfy AT, *Ross SA.  Non-Cannabinoid Constituents from a High Potency Cannabis sativa variety. National Center for Natural Products Research Annual Poster Session. University, MS. October 31, 2008.

Rahman Z, *Battu S, *Majumdar S, Gul W, ElSohly MA, *Repka MA. Physicochemical characterization of a novel delta-9 tetrahydrocannabinol prodrug, ELI-UN1-88-4. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. November 2008.  Atlanta, GA.

*Ross S, *Ivey K, *Ahmed S, Radwan M, *Elisnger A, *Slade D, ElSohly M, Matsumoto R, *El-Alfy A. Evaluation of Cannabinoids for Antidepressant-like Actions in Behavioral Despair Rodent Models. National IDeA Meeting. Washington, DC. August 6-8, 2008.

*Ross SA, *Slade D, Ahmed S, *Radwan M, ElSohly M. New cannabinoids from high potency Cannabis sativa L. ICRS Conference. Aviemore, Scotland. June 24-28, 2008.

*Ross, SA, *Slade D, Ahmed S, *Radwan M, ElSohly M. New cannabinoids from high potency Cannabis sativa L. 7th Meeting of the Association Francophone pour l’Enseignement et la Recherche en Pharmacognosie (AFERP), American Society of Pharmacognosy (ASP), Society of Medicinal Plant Research (GA), Phytochemical Society of Europe (PSE), and Societa` Italiana di Fitochimica (SIF). Athens, Greece. August 3-8, 2008.

*Ross SA, *Slade D, Ahmed S, *Radwan M, ElSohly M. New cannabinoids from high potency Cannabis sativa L. National Center for Natural Products Research Annual Poster Session. University, MS. October 31, 2008.

*Sammeta SM, Vaka SRK, *Murthy NS. Electrically Mediated Transdermal Delivery of Doxepin for Sustained Release Effect in Treatment of Postherpetic Neuralgia. Neuroscience and Behavior Research Day. Jackson, MS December 3, 2008.

*Sammeta SM, Vaka, SRK, *Murthy N. Noninvasive Transutaneous Delivery of HPbetaCD-Doxepin Complex for Sustained Release. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Atlanta, GA. November 2008.

*Seale S, *El-Alfy A. Acrylamide-induced behavioral neurotoxicity in male Wistar rat pups. National Center for Natural Products Research Annual Poster Session. University, MS.  October 31, 2008.

*Seale S, *El-Alfy A. Acrylamide-induced behavioral neurotoxicity in male Wistar rat pups.  Neuroscience & Behavior Research Day. Jackson, MS. December 3, 2008.

Singh A, *Upadhye SB, *Repka MA. Effect of modified cyclodextrin on hot-melt extruded films containing clotrimazole produced by twin-screw extrusion technology. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Atlanta, GA.  November 2008.

Singh A, Deng W, *Battu SK, Mohammed NN, Jo S, *Repka MA. Influence of Drug and Drug Load on the Mechanical Propertied of Hot-Melt Extruded Polyethylene Oxide Films. National Center for Natural Products Research Annual Poster Session. University, MS. October 31, 2008.

Singh A, Deng W, *Battu SK, Mohammed NN, Jo S, *Repka MA. Influence of Drug and Drug Load on the Mechanical Propertied of Hot-Melt Extruded Polyethylene Oxide Films.  American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Atlanta, GA. November 2008.

*Srirangam R, *Majumdar S. Ocular Delivery of Hesperidin – A Promising Candidate for Diabetic Retinopaty. Sigma Xi Poster Symposium. Oxford, MS. April 2008.

*Srirangam R, *Majumdar S. Permeability Characteristics and Intravitreal Pharmacokinetics of Hesperidin. Neuroscience & Behavior Research Day. Jackson, MS. December 3, 2008.

*Srirangam R, *Majumdar S. Physicochemical Characteristics and In Vitro Ocular Tissue Permeability of Hesperidin: a Natural Bioflavonoid. National Center for Natural Products Annual Poster Presentation. University, MS. October 31, 2008.

*Srirangam R, *Majumdar S. Physicochemical Characteristics and in vitro ocular tissue permeability of Hesperidin: A natural bioflavonoid. American Association of Pharmaceutical Scientists Annual Meeting. Atlanta, GA. November 2008.

*Srirangam R, *Majumdar S. Solubility and ocular tissue permeability of Hesperidin. SRDG-Pharmforum. May 2008. Little Rock, AR.

*Thumma S, Singh A, *Majumdar S, ElSohly MA, Gul W, *Repka MA. Enhancement of the dissolution and handling properties of an ester prodrug of delta-9-tetrahydrocannabinol by a solid dispersion technique. American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Atlanta, GA. November 2008.

*Thumma S, Singh A, *Majumdar S, ElSohly MA, Gul W, *Repka MA. Evaluation of non-ionic surfactants for transmucosal delivery of a pro-drug of delta-9-tetrahydrocannabinol. Sigma-Xi Poster Symposium. University, MS. April 2008.

*Thumma S, Singh A, *Majumdar S, ElSohly MA, Gul W, *Repka MA. Evaluation of non-ionic surfactants for transmucosal delivery of a pro-drug of delta-9-tetrahydrocannabinol. SRDG-PharmForum. Little Rock, AR. May 2008.

*Upadhye S, Singh A, *Majumdar S, *Repka MA. Effect of random methylated beta cyclodextrin on aqueous solubility, stability and permeation of the hemisuccinate ester of delta-9-tetrahydrocannabinol. National Center for Natural Products Research Annual Poster Session. University, MS. October 31, 2008.

*Upadhye S, *Majumdar S, *Kulkarni S, Avery MA, Gul W, ElSohly MA, *Repka MA.  Improving solubility and stability of hemisuccinate ester prodrug of delta-9-tetrahydrocannabinol with cyclodextrin complexation. Annual Neuroscience and Behavior Research Day. Jackson, MS. December 3, 2008.

*Upadhye S, *Majumdar S, Jefferson T, Gul W, ElSohly MA, *Repka MA. Preformulation characterization of a prodrug of delta-9 tetrahydrocannabinol (THC-XIX645). American Association of Pharmaceutical Scientists Annual Meeting and Exposition. Atlanta, GA.  November 9, 2008.

*Upadhye S, *Majumdar S, Gul W, ElSohly MA, *Repka MA. Preformulation Evaluation of delta-9-tetrahydrocannabinol Prodrugs. Sigma-Xi Poster Symposium. April 2008.  University, MS.

*Upadhye S, *Majumdar S, Gul W, ElSohly MA, *Repka MA. The influence of inclusion complex formation with random methylated beta cyclodextrin (RAMEB) on thermal stability and permeation characteristics of the hemisuccinate prodrug of delta-9-tetrahydrocannabinol.  American Association of Pharmaceutical Scientists Annual Meeting and Exposition.  November 9, 2008. Atlanta, GA.

Vaka SRK, *Sammeta SM, *Murthy SN. Effect of permeation enhancers on brain uptake of intranasally administered Nerve Growth Factor. American Association of Pharmaceutical Scientists Annual meeting and Exposition. Atlanta, GA. November 16-20, 2008.

Vaka SRK, *Sammeta SM, *Murthy SN. Enhancement of brain uptake of intranasally administered Nerve Growth Factor by peppermint oil. PharmForum. Little Rock, Arkansas. May 18-20, 2008 Oral Presentation.

*Wilson L, *Harrell S, *Ross SA, Ahmed S, *Radwan M, *Slade D, *Khan I, ElSohly M, *El-Alfy A. Effect of cannabinoids on food intake in mice. South Central Chapter of the Society of Toxicology Meeting. Jefferson, AR. September 19, 2008.

*Wilson L, *Harrell S, *Ross SA, Ahmed S, *Radwan M, *Slade D, *Khan I, ElSohly M, *El-Alfy A. Effect of cannabinoids on food intake in mice. National Center for Natural Products Research Annual Poster Session. University, MS. October 31, 2008.

*Wilson L, *Harrell S, *Ross SA, Ahmed S, *Radwan M, *Slade D, *Khan I, ElSohly M, *El-Alfy A. Effect of cannabinoids on food intake in mice. Neuroscience and Behavior Research Day. Jackson, MS. December 3, 2008.

*Wu M, Ali Z, *Khan IA, Dasmahapatra A. Preliminary Molecular Mechanism of Blue Cohosh (Caulophyllum thalictroides) Toxicity on Cardiovascular System of Japanese Medaka (Oryzias latipes). National Center for Natural Products Research Annual Poster Session.  October 31, 2008. University, MS.

*Zhou YD. Alpinumisoflavone, Methylalpinumisoflavone and Rotenone – Lonchocarpus glabrescens Metabolites that Inhibit HIF-1 Activation and Tumor Cell Migration. 7th Oxford International Conference on Science of Botanicals & American Society of Pharmacognasy 4th Interim Meeting. University, MS. April 12 - 16, 2008. Oral Presentation.

*Zhou YD, Nagle DG, Veena CK, Liu Y, *Morgan JB, Jekabsons MB, Johnson RS, Chowdhury FH, Mora FD. Pharmacological and Preclinical Evaluation of Manassantins: Potent Inhibitors of Hypoxia-Induced HIF-1 Activation. Phytochemical Society of Europe Symposium on Natural Products in Cancer Therapy. Naples, Italy. September 23 - 26, 2008.  Oral Presentation

Year 2

*Adkins J, Moraes N, White N, Tadlock LA, Nieto MJ, *McCurdy CR. HPLC method validation for determination of mitragynine, an indole alkaloid, in crude extracts of Mitragyna speciosa. International Narcotics Research Conference (INRC), Berlin, Germany, July 8-13, 2007.

*Adkins J, Moraes NV, Nieto MJ, *McCurdy CR., Quantification of Mitragynine, an Opioid agonist, in crude extracts of different chemotypes of Mitragyna speciosa by HPLC. SERMACS 2007, Greenville, SC, October 2007.

Battu SK, Boddu S, *Majumdar S, *Repka MA. Effect of Processing Conditions and Formulation Additives on Chemical Stability of a Δ9 – Tetrahydrocannabinol Pro-drug in Polymeric Matrices Produced by a Hot-Melt Method. AAPS Pharm Sci, Annual AAPS National Meeting, San Diego, CA, November 12th, 2007.

*Bowling J, Karamyan VT, Speth RC, Sufka KJ, *Hamann MT. Pharmacological investigation of observed anxiolytic effects of the marine natural product aaptamine. 7th Annual Oxford International Conference on the Science of Botanicals & American Society of Pharmacognosy 4th Interim Meeting, Oxford, MS, April 2008

*El-Alfy, A, *Ross S, *Childress S, *Wilson L, Xu YT, Viard E, Radwan M, Ahmed S, *Slade D, ElSohly M, Matsumoto, R. Pharmacological Characterization of Minor Cannadinoid Constituents. Experimental Biology 2008, San Diego, CA, April 5-10, 2008.

*El-Alfy A, *Ivey K, *Wilson L, *Childress S, Abourashed E, Matsumoto R, ElSohly M. Towards a Better Understanding of the Psychopharmacology of Nutmeg – Observed Activities in the Mouse Tetrad Assay. Seventh Annual Oxford International Conference on the Science of Botanicals and American Society of Pharmacognosy fourth Interim Meeting, April 12-16, 2008, Oxford, MS.

Franklin D, *Wilson L, Cui J, *Adkins J, *McCurdy C, *Matsumoto R, *El-Alfy A. Antinociceptive action of mitragynine and its synthetic analogs in mice. Annual Meeting of the South Central Chapter of the Society of Toxicology (SCC/SOT), September 27-28, 2007, Oxford, MS.

Franklin L, *Wilson L, Cui J, *Adkins J, *McCurdy C, Matsumoto R, *El-Alfy A. Antinociceptive Action of Mitragynine and its Synthetic Analogs in Mice. Seventh Annual Oxford International Conference on the Science of Botanicals and American Society of Pharmacognosy fourth Interim Meeting, April 12-16, 2008, Oxford, MS.

*Ivey K, *Childress S, Diers J, Kochanowska A, Ali M, Kelly M, *Hamann M, *Matsumoto R, *El-Alfy A. Antidepressant action of brominated indole alkaloids isolated from marine sponges and their synthetic analogs. Annual Meeting of the South Central Chapter of the Society of Toxicology (SCC/SOT), September 27-28, 2007, Oxford, MS.

*Ivey K, *Ross S, Ahmed S, Radwan M, *Elisnger A, *Slade D, ElSohly M, Matsumoto R, *El-Alfy A. Evaluation of Delta9-Tetrahydrocannabinol and other Cannabinoids for Antidepressant-like Actions in the Mouse Forced Swim Test. Seventh Annual Oxford International Conference on the Science of Botanicals and American Society of Pharmacognosy fourth Interim Meeting, April 12-16, 2008, Oxford, MS.

*Kaushal N, Croom C, Shaikh J, *Narayanan S, Mesangeau C, Poupaert JH, *McCurdy CR, *Matsumoto RR. SN79- A novel sigma-2 receptor antagonist, attenuates cocaine induced behaviors in mice. Annual Meeting of the South Central Chapter of the Society of Toxicology (SCC/SOT), September 27-28, 2007, Oxford, MS.

*Kaushal N, Croom C, Shaikh J, Narayanan S, Mesangeau C, Poupaert JH, *McCurdy CR, *Matsumoto RR. SN79- A novel sigma-2 receptor antagonist, attenuates cocaine induced behaviors in mice. Annual NCNPR poster session, Oxford, Mississippi, Oct. 5, 2007

*Kaushal N, Croom C, Shaikh J, *Narayanan S, Mesangeau C, Poupaert JH, *McCurdy CR, Matsumoto RR. "SN79- A novel sigma-2 receptor antagonist, attenuates cocaine induced behaviors in mice”. ASPET Experimental Biology annual meeting April 5-9, 2008, San Diego, CA.

Madar ZS Discovery of Novel Prolylcarboxypeptidase function. Gordon Conference, ANGIOTENSIN, Feb 24-29, 2008, Ventura, CA

Madar ZS Plasma kallikrein-kinin system and endothelial cell activation. Experimental Biology, April 5-9, 2008, San Diego, CA

*Majumdar, S., *Upadhye, SB, Thumma S, Battu SK, Gul W, ElSohly MA, *Repka MA. “Evaluation of transbuccal delivery of tetrahydrocannabinol using hot-melt extruded transmucosal patch systems”, AAPS Annual meeting 2007, San Diego, CA, November 12th, 2007

*Matsumoto RR, *Wilson, LL, Mesangeau C, Shaikh J, *Kaushal N, Poupaert JH, *McCurdy CM., CM156, a novel substituted piperazine, attenuates the behavioural effects of cocaine in mice. Annual NCNPR poster session, Oxford, Mississippi, Oct. 5, 2007

*Prasanna S, Daga PD, Clark S, Tosso PN, Xie A, Odde S, Duan JR, *Doerksen RJ. Computational Investigations of Protein-Ligand Interactions. 2007 National EPSCoR Meeting, Hawaii, November 2007.

Repka MA Extrusion of PEO films and protection of sensitive actives during extrusion. APV Experts’ Workshop on Hot- melt extrusion and its use in the manufacturing of pharmaceutical dosage forms, Ludwigshafen, Germany, March 4th-5th 2008.

*Sivaprakasam P, *Hamann MT, *Doerksen RJ. Manzamine A Interaction with CDK5: Docking, Molecular Dynamics Simulations and Binding Free Energy Calculations. 16th Conference on Current Trends in Computational Chemistry, November 2-3, 2007, Jackson, MS

*Slade D, Ahmed SA, *Ross SA, Radwan MM, Zulfiqar F, and ElSohly MA., Phytochemical Analysis of Cannabis Sativa L.: Part 1. New Cannabinoid Esters from Cannabis., The 4th Conference on Cannabinoids in Medicine, Cologne, Germany (October 2007).

Thumma S, ElSohly MA, *Repka MA. Bioadhesive Properties of Hot-Melt Produced Poly (Ethylene Oxide) Films for Transmucosal Delivery of a Pro-Drug of Delta-9-Tetrahydrocannabinol. AAPS Annual Meeting and Exposition, San Diego, CA, November 12th 2007.

Thumma S, *Majumdar S, ElSohly MA, *Repka, MA. Chemical Stability of a Pro-Drug of Delta-9-Tetrahydrocannabinol: Effect of Processing Variables and Plasticizers.  AAPS Annual Meeting and Exposition, San Diego, CA, November 12th 2007.

Thumma S, Singh A, ElSohly MA, *Repka MA. Evaluation of Non-ionic Surfactants for Transmucosal Delivery of a Pro-drug of Delta-9-Tetrahydrocannabinol. AAPS Annual Meeting and Exposition, San Diego, CA, November 12th 2007.

Thumma S, ElSohly MA, *Repka MA. Transmucosal Delivery of a Pro-drug of Delta-9-Tetrahydrocannabinol: Effect of Formulation additives. AAPS Annual Meeting and Exposition, San Diego, CA, November 12th 2007.

*Wilson L, *Ivey K, *Ross S, Ahmed S, Radwan M, *Slade D, ElSohly M, Matsumoto R, *El-Alfy A. Behavioral Effects of the Novel Cannabinoid SAAB-38-7 in Mouse Tetrad Assay. Seventh Annual Oxford International Conference on the Science of Botanicals and American Society of Pharmacognosy fourth Interim Meeting, April 12-16, 2008, Oxford, MS.

*Wilson L, *Childress S, Radwan M, Ahmed S, *Ross S, *Slade D, ElSohly M, *Matsumoto R, *El-Alfy A. Pharmacological evaluation of minor cannabinoid constituents of Cannabis sativa L. Annual Meeting of the South Central Chapter of the Society of Toxicology (SCC/SOT), September 27-28, 2007, Oxford, MS

*Wu M, Ali Z, *Khan IA, Dasmahapatra A., Gata2: A potential candidate gene of blue Cohosh toxicity in Japanese madaka cardiovascular development. Sigama Xi 2008 Student Research Poster Symposium, Oxford, MS, April 2008

Year 1

Adkins JE, Moraes NV, White N, Tadlock L , Nieto MJ, McCurdy CR. Isolation, purification and identification of indole alkaloids from Mitragyna speciosa with simultaneous determination by LC and UPLC/MS methods. 2006 AAPS Annual Meeting and Exposition, San Antonio, TX, Oct. 29 - Nov. 2, 2006.

Hamann MT. "The genesis of two fields from a common Caribbean sponge: nucleoside antiviral agents and marine natural products chemistry", Emory University and the VA Hospital in Atlanta Georgia. (2007)

Kutrzeba LM, Dayan FE, Howell J, Feng J, Giner JL, Zjawiony JK. "Biosynthesis of the Hallucinogenic Neoclerodane Diterpenoid Salvinorin A Proceeds via the Deoxyxylulose Phosphate Pathway", TERPNET, Strasbourg,
France, April 30 - May4, 2007.

Matsumoto RR, Wilson LL, Mesangeau C, Diers J, Shaikh J, Poupaert JH, McCurdy CR.  "CMl56, a novel substituted piperazine, attenuatetes the behavioral effects of cocaine in mice." College of Problems on Drug Dependence annual meeting. Accepted for
Presentation, June16-17, 2007.

Munjal M., Upadhye S., ElSohly M .A., Repka M.A. Effect of Formulation and Physiological Variables on Permeation of Δ9 – Tetrahydrocannabinol, The AAPS Journal Supplement volume 8 Issue S2, W4320, Annual AAPS National Meeting, San Antonio, TX. (2006)

Munjal M, Thumma S, ElSohly MA, Repka MA. Factors Affecting Oxidation of Δ9- Tetrahydrocannabinol in Hot - Melt Polymeric Films, The AAPS Journal Supplement, Volume 8 Issue S2, R6108, Annual AAPS National Meeting, San Antonio, TX. (2006)

Munjal M, Battu S, ElSohly MA, Repka MA. Mechanistic Understanding of Dissolution Properties of Physical Mixtures and Hot - Melt Polyethylene Oxide Matrices Containing Δ9 –Tetrahydrocannabinol, The AAPS Journal Supplement, Volume 8 Issue S2, W5280, Annual AAPS National Meeting, San Antonio, TX. (2006)

Munjal M., Majumdar S ., ElSohly M.A., Repka M.A. Reduced Oxidation of Δ9-Tetrahydrocannabinol Hot -Melt Polyethylene Oxide - Vitamin E Succinate Films Utilizing Anti-oxidants, The AAPS Journal Supplement volume 8 Issue S2, R6112, Annual AAPS National Meeting, San Antonio, TX. (2006)

Singh N, Cheve G, Ferguson DM, McCurdy CR. Delineating a Powerful Virtual Screening Protocol for G-Protein Coupled Receptors: Application to Selective Kappa Opioid Receptor Agonist, Salvinorin A. Pharmaceutical Sciences World Congress-Optimizing Drug Therapy:  An Imperative For World Health, Amsterdam, Netherlands Apr.22nd -25th, 2007.

Singh N , McCurdy CR. A Chemical Function Based Pharmacophore Development and Validation for Kappa Opioid Receptor Agonist. 232nd National American Chemical Society (ACS) meeting, Sept.10-14, San Francisco, CA, 2006.

Thumma S, ElSohly MA, Repka MA. Preformulation Studies of a Pro-drug of Delta-9-Tetrahydrocannabinol, The AAPS Journal Supplement, Volume 8 Issue S2, W4112, Annual AAPS National Meeting, San Antonio, TX. (2006)