2012 Publications: (* = Recently Added To List)

Brents LK, Medina-Bolivar F, Seely KA, Nair V, Bratton SM, Nopo-Olazabal L, Patel RY, Liu H, Doerksen RJ, Prather PL, Radominska-Pandya A. Natural prenylated resveratrol analogs arachidin-1 and -3 demonstrate improved glucuronidation profiles and have affinity for cannabinoid receptors. Xenobiotica. 2012 Feb;42(2):139-56. doi: 10.3109/00498254.2011.609570. Epub 2011 Oct 4. PMID: 21970716 (JI Project - Doerksen) *

Hingorani T, Gul W, Elsohly M, Repka MA, Majumdar S. Effect of ion pairing on in vitro transcorneal permeability of a Δ(9) -tetrahydrocannabinol prodrug: potential in glaucoma therapy. J Pharm Sci. 2012 Feb;101(2):616-26. doi: 10.1002/jps.22791. Epub 2011 Oct 11. PMID: 21989812 (Small Grant - Majumdar) *

2011 Publications: (* = Recently Added To List)

Chajkowski SM, Mallela J, Watson DE, Wang J, McCurdy CR, Rimoldi JM, Shariat-Madar Z.  Highly selective hydrolysis of kinins by recombinant prolylcarboxypeptidase.  Biochem Biophys Res Commun. 2011 Feb 18;405(3):338-43. Epub 2010 Dec 16. PMID: 21167814 (JI Project 8 - Shariat-Madar; Chemistry Core)

Duan L, Motchoulski N, Danzer B, Davidovich I, Shariat-Madar Z, Levenson VV.  Prolylcarboxypeptidase regulates proliferation, autophagy, and resistance to 4-hydroxytamoxifen-induced cytotoxicity in estrogen receptor-positive breast cancer cells. J Biol Chem. 2011 Jan 28;286(4):2864-76. Epub 2010 Nov 17. PMID: 21087932 (JI Project 4 - Zhou)

Gao J, León F, Radwan MM, Dale OR, Husni AS, Manly SP, Lupien S, Wang X, Hill RA, Dugan FM, Cutler HG, Cutler SJ.  Benzyl Derivatives with in Vitro Binding Affinity for Human Opioid and Cannabinoid Receptors from the Fungus Eurotium repens.  J Nat Prod. 2011 Jun 22;74(7):1636-9. Epub 2011 Jun 13.  PMID: 21667972 (In Vitro Pharmacology Core; Sourcing, Acquisition and Isolation Core)

Garripelli VK, Kim JK, Son S, Kim WJ, Repka MA, Jo S. Matrix metalloproteinase-sensitive thermogelling polymer for bioresponsive local drug delivery. Acta Biomater. 2011 May;7(5):1984-92. Epub 2011 Feb 17. PMID: 21300184 (JI Project 2 - Repka/Majumdar)

Guitart C, Slattery M, Ankisetty S, Radwan M, Ross SJ, Letcher RJ, Reddy CM. Contemporary 14C radiocarbon levels of oxygenated polybrominated diphenyl ethers (O-PBDEs) isolated in sponge-cyanobacteria associations. Mar Pollut Bull. 2011 Mar;62(3):631-6. Epub 2011 Jan 28. PMID: 21276990 (Sourcing, Acquisition and Isolation Core)

Hippalgaonkar K, Gul W, ElSohly MA, Repka MA, Majumdar S. Enhanced solubility, stability, and transcorneal permeability of delta-8-tetrahydrocannabinol in the presence of cyclodextrins. AAPS PharmSciTech. 2011 Jun;12(2):723-31. Epub 2011 Jun 3. PMID: 21637944 (Small Grant - Majumdar) *

Huckabee DB, Jekabsons MB. Identification of Bax-voltage-dependent anion channel 1 complexes in digitonin-solubilized cerebellar granule neurons. J Neurochem. 2011 Dec;119(5):1137-50. doi: 10.1111/j.1471-4159.2011.07499.x. Epub 2011 Oct 24. PMID: 21951169 (Small Grant - Jekabsons) *

Kaushal N, Robson MJ, Vinnakota H, Narayanan S, Avery BA, McCurdy CR, Matsumoto RR. Synthesis and pharmacological evaluation of 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a cocaine antagonist, in rodents. AAPS J. 2011 Sep;13(3):336-46. Epub 2011 Apr 15. PMID: 21494909 (JI Project 1 - McCurdy) *

Kolte D, Bryant J, Holsworth D, Wang J, Akbari P, Gibson G, Shariat-Madar Z.  Biochemical characterization of a novel high-affinity and specific plasma kallikrein inhibitor.  Br J Pharmacol. 2011 Apr;162(7):1639-49. PMID: 21175583 (JI Project 8 - Shariat-Madar)

Kolte D, Osman N, Yang J, Shariat-Madar Z. High molecular weight kininogen activates B2 receptor signaling pathway in human vascular endothelial cells. J Biol Chem. 2011 Jul 15;286(28):24561-71. Epub 2011 May 17. PMID: 21586566 (JI Project 8 - Shariat-Madar) *

Manda P, Hargett JK, Kiran Vaka SR, Repka MA, Narasimha Murthy S.  Delivery of cefotaxime to the brain via intranasal administration.  Drug Dev Ind Pharm. 2011 Nov;37(11):1306-10. Epub 2011 Jun 27.  PMID: 21702731 (JI Project 7 - Murthy)

Nan X, Fu G, Zhao Z, Liu S, Patel RY, Liu H, Daga PR, Doerksen RJ, Dang X, Chen Y, Wilkins D. Leveraging domain information to restructure biological prediction. BMC Bioinformatics. 2011 Oct 18;12 Suppl 10:S22. PMID: 22166097 (JI Project 6 - Doerksen) *

Sammeta SM, Repka MA, Narasimha Murthy S. Magnetophoresis in combination with chemical enhancers for transdermal drug delivery. Drug Dev Ind Pharm. 2011 Sep;37(9):1076-82. Epub 2011 Mar 30. PMID: 21449699 (JI Project 7 - Murthy) *

Sobolev VS, Khan SI, Tabanca N, Wedge DE, Manly SP, Cutler SJ, Coy MR, Becnel JJ, Neff SA, Gloer JB.  Biological Activity of Peanut (Arachis hypogaea) Phytoalexins and Selected Natural and Synthetic Stilbenoids.  J Agric Food Chem. 2011 Mar 9;59(5):1673-82. Epub 2011 Feb 11.  PMID: 21314127 (In Vitro Pharmacology Core)

Tomioka T, Yabe Y, Takahashi T, Simmons TK.  DIBAL-Mediated Reductive Transformation of trans-Dimethyl Tartrate Acetonide into ε-Hydroxy α,β-Unsaturated Ester and Its Derivatives.  J Org Chem. 2011 Jun 3;76(11):4669-74. Epub 2011 Apr 29.  PMID:21526866 (Small Grant - Tomioka)

Vaka SR, Murthy SN, Repka MA, Nagy T. Upregulation of endogenous neurotrophin levels in the brain by intranasal administration of carnosic acid. J Pharm Sci. 2011 Aug;100(8):3139-45. doi: 10.1002/jps.22528. Epub 2011 Mar 1. PMID: 21360710 (JI Project 7 - Murthy) *

Wang X, Habib E, León F, Radwan MM, Tabanca N, Gao J, Wedge DE, Cutler SJ. Antifungal metabolites from the roots of Diospyros virginiana by overpressure layer chromatography. Chem Biodivers. 2011 Dec;8(12):2331-40. doi: 10.1002/cbdv.201000310. PMID: 22162171 (Sourcing, Acquisition and Isolation Core)

2010 Publications:

Battu SK, Repka MA, Maddineni S, Chittiboyina AG, Avery MA, Majumdar S.  Physicochemical characterization of berberine chloride: a perspective in the development of a solution dosage form for oral delivery. AAPS PharmSciTech 2010 Sep;11(3):1466-75. Epub 2010 Sep 15. PMID: 20842541 (Small Grant - Majumdar)

Coothankandaswamy V, Liu Y, Mao SC, Morgan JB, Mahdi F, Jekabsons MB, Nagle DG, Zhou YD. The alternative medicine pawpaw and its acetogenin constituents suppress tumor angiogenesis via the HIF-1/VEGF pathway. J Nat Prod. 2010 May 28;73(5):956-61. PMID: 20423107 (JI Project 4 - Zhou)

Daga PR, Duan J, Doerksen RJ.  Computational model of hepatitis B virus DNA polymerase: molecular dynamics and docking to understand resistant mutations.  Protein Sci. 2010 Apr;19(4):796-807. PMID: 20162615 (JI Project 6 - Doerksen)

Daga PR, Patel RY, Doerksen RJ.  Template-based protein modeling: recent methodological advances.  Curr Top Med Chem. 2010;10(1):84-94. PMID: 19929829 (JI Project 6 - Doerksen)

El-Alfy AT, Ivey K, Robinson K, Ahmed S, Radwan M, Slade D, Khan I, ElSohly M, Ross S.  Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L. Pharmacol Biochem Behav. 2010 Jun;95(4):434-42. Epub 2010 Mar 21. PMID: 20332000 (JI Project 5 - El-Alfy; Sourcing, Acquisition and Isolation Core; In Vivo Pharmacology Core)

Galal AM, Gul W, Noreddin AM, Slade D. An update on the synthesis and antibacterial effects of carbapenems. Recent Pat Antiinfect Drug Discov. 2010 Jan 1;5(1):23-43. PMID: 19929840 (Sourcing, Acquisition and Isolation Core)

Garripelli VK, Kim JK, Namgung R, Kim WJ, Repka MA, Jo S.  A novel thermosensitive polymer with pH-dependent degradation for drug delivery.  Acta Biomater. 2010 Feb;6(2):477-85. Epub 2009 Jul 22.  PMID: 19596093 (JI Project 2 - Repka/Majumdar)

Kim JK, Garripelli VK, Jeong UH, Park JS, Repka MA, Jo S. Novel pH-sensitive polyacetal-based block copolymers for controlled drug delivery. Int J Pharm. 2010 Nov 30;401(1-2):79-86. Epub 2010 Aug 27. PMID: 20801203 (JI Project 2 - Repka/Majumdar)

Kochanowska-Karamyan AJ, Hamann MT. Marine indole alkaloids: potential new drug leads for the control of depression and anxiety. Chem Rev. 2010 Aug 11;110(8):4489-97. PMID: 20380420 (Chemistry Core)

Kulkarni SJ, Pedduri Y, Chittiboyina AG, Avery MA. Asymmetric total synthesis of the caspase-1 inhibitor (-)-berkeleyamide A. J Org Chem. 2010 May 7;75(9):3113-6. PMID: 20356061 (Chemistry Core)

Li J, Jadhav AN, Khan IA.  Triterpenoids from Brazilian ginseng, Pfaffia paniculata.  Planta Med. 2010 Apr;76(6):635-9. Epub 2009 Nov 25.  PMID: 19941264 (Sourcing, Acquisition and Isolation Core)

Liu H, McCurdy CR, Doerksen RJ.  Computational Study on the Conformations of Mitragynine and Mitragynaline.  Theochem. 2010 Apr 15;945(1-3):57-63.  PMID: 21293786 (JI Project 6 - Doerksen)

Majumdar S, Hingorani T, Srirangam R. Evaluation of active and passive transport processes in corneas extracted from preserved rabbit eyes. J Pharm Sci. 2010 Apr;99(4):1921-30. PMID: 19890936 (Small Grant - Majumdar)

Majumdar S, Srirangam R. Potential of the bioflavonoids in the prevention/treatment of ocular disorders. J Pharm Pharmacol. 2010 Aug;62(8):951-65. PMID: 20663029 (Small Grant - Majumdar)

Morgan JB, Mahdi F, Liu Y, Coothankandaswamy V, Jekabsons MB, Johnson TA, Sashidhara KV, Crews P, Nagle DG, Zhou YD. The marine sponge metabolite mycothiazole: a novel prototype mitochondrial complex I inhibitor. Bioorg Med Chem. 2010 Aug 15;18(16):5988-94. Epub 2010 Jun 25. PMID: 20637638 (JI Project 4 - Zhou)

Murthy SN, Sammeta SM, Bowers C. Magnetophoresis for enhancing transdermal drug delivery: Mechanistic studies and patch design. J Control Release. 2010 Dec 1;148(2):197-203. Epub 2010 Aug 20. PMID: 20728484 (JI Project 7 - Murthy)

Na M, Ding Y, Wang B, Tekwani BL, Schinazi RF, Franzblau S, Kelly M, Stone R, Li XC, Ferreira D, Hamann MT.  Anti-infective discorhabdins from a deep-water alaskan sponge of the genus Latrunculia.  J Nat Prod. 2010 Mar 26;73(3):383-7.  PMID: 20337497 (Chemistry Core)

Peng J, Kudrimoti S, Prasanna S, Odde S, Doerksen RJ, Pennaka HK, Choo YM, Rao KV, Tekwani BL, Madgula V, Khan SI, Wang B, Mayer AM, Jacob MR, Tu LC, Gertsch J, Hamann MT.  Structure-activity relationship and mechanism of action studies of manzamine analogues for the control of neuroinflammation and cerebral infections.  J Med Chem. 2010 Jan 14;53(1):61-76.  PMID: 20017491 (JI Project 6 - Doerksen)

Sammeta SM, Vaka SR, Murthy SN. Transcutaneous electroporation mediated delivery of doxepin-HPCD complex: a sustained release approach for treatment of postherpetic neuralgia. J Control Release. 2010 Mar 19;142(3):361-7. Epub 2009 Nov 14. PMID: 19922748 (JI Project 7 - Murthy)

Shariat-Madar B, Kolte D, Verlangieri A, Shariat-Madar Z.  Prolylcarboxypeptidase (PRCP) as a new target for obesity treatment.  Diabetes Metab Syndr Obes. 2010 Apr;3:67-78.  PMID: 20694162 (Small Grant - Shariat-Madar)

Srirangam R, Majumdar S. Passive asymmetric transport of hesperetin across isolated rabbit cornea. Int J Pharm. 2010 Jul 15;394(1-2):60-7. Epub 2010 May 9.  PMID: 20438820 (Small Grant - Majumdar)

Sun L, Shah F, Helal MA, Wu Y, Pedduri Y, Chittiboyina AG, Gut J, Rosenthal PJ, Avery MA. Design, synthesis, and development of novel guaianolide-endoperoxides as potential antimalarial agents. J Med Chem. 2010 Nov 11;53(21):7864-8. PMID: 20945914 (Chemistry Core)

Upadhye SB, Kulkarni SJ, Majumdar S, Avery MA, Gul W, ElSohly MA, Repka MA.  Preparation and characterization of inclusion complexes of a hemisuccinate ester prodrug of delta9-tetrahydrocannabinol with modified beta-cyclodextrins. AAPS PharmSciTech. 2010 Jun;11(2):509-17. Epub 2010 Mar 24. PMID: 20333489 (JI Project 2 - Repka/Majumdar)

Vaka SR, Murthy SN.  Enhancement of nose-brain delivery of therapeutic agents for treating neurodegenerative diseases using peppermint oil.  Pharmazie. 2010 Sep;65(9):690-2.  PMID: 21038847 (JI Project 7 - Murthy)

Wahba AE, Hamann MT. New one-pot methodologies for the modification or synthesis of alkaloid scaffolds. Mar Drugs. 2010 Aug 24;8(8):2395-416. PMID: 20948914 (Chemistry Core)

Xu YT, Kaushal N, Shaikh J, Wilson LL, Mésangeau C, McCurdy CR, Matsumoto RR.  A novel substituted piperazine, CM156, attenuates the stimulant and toxic effects of cocaine in mice. J Pharmacol Exp Ther. 2010 May;333(2):491-500. Epub 2010 Jan 25. PMID: 20100904 (JI Project 1 - McCurdy; In Vivo Pharmacology Core)

2009 Publications:

Boddu SP, Yamsani MR, Potharaju S, Veeraraghavan S, Rajak S, Kuma SV, Avery BA, Repka MA, Varanasi VS. Influence of grapefruit juice on the pharmacokinetics of diltiazem in Wistar rats upon single and multiple dosage regimens. Pharmazie 2009 Aug;64(8):525-31. PMID: 19746842 (JI Project 2 - Repka/Majumdar)

Bryant JW, Shariat-Madar Z.  Human plasma kallikrein-kinin system: physiological and biochemical parameters.  Cardiovasc Hematol Agents Med Chem 2009 Jul;7(3):234-50. PMID: 19689262 (Small Grant - Shariat-Madar)

Carvalho P, Furr III EB*, McCurdy CR*. (E)-methyl 2-((2S,3S,12bR)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo [2,3-a]quinolizin-2-yl)-3-methoxyacrylate. Acta Crystallographica, Section E: Structure Reports Online, 2009, E65, o1441-o1442. Web Published 5-29-2009. DOI: 10.1107/S1600536809017309. PMCID: 2969786 (JI Project 1 - McCurdy)

de Moraes NV, Moretti RA, Furr EB 3rd, McCurdy CR, Lanchote VL.  Determination of mitragynine in rat plasma by LC-MS/MS: application to pharmacokinetics.  J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Aug 15;877(24):2593-7. Epub 2009 Jun 21. PMID: 19589735 (JI Project 1 - McCurdy)

El-Alfy AT, Wilson L, ElSohly MA, Abourashed EA.  Towards a better understanding of the psychopharmacology of nutmeg: Activities in the mouse tetrad assay.  J Ethnopharmacol. 2009 Nov 12;126(2):280-6. Epub 2009 Aug 22.  PMID: 19703539 (JI Project 5 - El-Alfy; Sourcing, Acquisition and Isolation Core; In Vivo Pharmacology Core)

Galal AM, Slade D, Gul W, El-Alfy AT, Ferreira D, Elsohly MA.  Naturally occurring and related synthetic cannabinoids and their potential therapeutic applications.  Recent Pat CNS Drug Discov. 2009 Jun;4(2):112-36.  PMID: 19519560 (In Vivo Pharmacology Core; Sourcing, Acquisition and Isolation Core)

Kim JK, Anderson J, Jun HW, Repka MA, Jo S. Self-assembling peptide amphiphile-based nanofiber gel for bioresponsive cisplatin delivery. Mol Pharm 2009 May-June;6(3):978-85. PMID: 19281184 (JI Project 2 - Repka/Majumdar)

Kudrimoti S, Ahmed SA, Daga PR, Wahba AE, Khalifa SI, Doerksen RJ, Hamann MT.  Semisynthetic latrunculin B analogs: studies of actin docking support a proposed mechanism for latrunculin bioactivity.  Bioorg Med Chem. 2009 Nov 1;17(21):7517-22. Epub 2009 Sep 16.  PMID: 19800245 (JI Project 6 - Doerksen)

León F, Habib E, Adkins JE, Furr EB, McCurdy CR, Cutler SJ.  Phytochemical characterization of the leaves of Mitragyna speciosa grown in U.S.A.  Nat Prod Commun. 2009 Jul;4(7):907-10.  PMID: 19731590 (JI Project 1 - McCurdy)

Liu Y, Veena CK, Morgan JB, Mohammed KA, Jekabsons MB, Nagle DG, Zhou YD. Methylalpinumisoflavone inhibits hypoxia-inducible factor-1 (HIF-1) activation by simultaneously targeting multiple pathways. J Biol Chem 2009 Feb 27;284(9):5859-68. Epub 2008 Dec 17. PMID: 19091749 (JI Project 4 - Zhou)

Liu Y, Morgan JB, Coothankandaswamy V, Liu R, Jekabsons MB, Mahdi F, Nagle DG, Zhou YD. The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration. J Nat Prod. 2009 Dec;72(12):2104-9. PMID: 19921787 (JI Project 4 - Zhou)

Majumdar S, Srirangam R. Solubility, stability, physicochemical characteristics and in vitro ocular tissue permeability of hesperidin: a natural bioflavonoid. Pharm Res 2009 May;26(5):1217-25. Epub 2008 Sep 23. PMID: 18810327 (Small Grant - Majumdar)

Mallela J, Yang J, Shariat-Madar Z. Prolylcarboxypeptidase: A cardioprotective enzyme. Int J Biochem Cell Biol 2009 Mar;41(3):477-81. Epub 2008 Feb 29. PMID: 18396440 (Small Grant - Shariat-Madar)

Prasanna S, Daga PR, Xie A, Doerksen RJ. Glycogen synthase kinase-3 inhibition by 3-anilino-4-phenylmaleimides: insights from 3D-QSAR and docking. J Comput Aided Mol Des 2009 Feb;23(2):113-27. Epub 2008 Oct 7. PMID: 18839067 (Small Grant - Doerksen)

Prasanna S, Doerksen RJ. Topological polar surface area: a useful descriptor in 2D-QSAR. Curr Med Chem 2009;16(1):21-41. PMID: 19149561 (Small Grant - Doerksen)

Radwan MM, Elsohly MA, Slade D, Ahmed SA, Khan A, Ross SA. Biologically Active Cannabinoids from High-Potency Cannabis sativa. J Nat Prod 2009 May 22;72(5):906-11. PMID: 19344127 (JI Project 3 - Ross; Sourcing, Acquisition and Isolation Core)

Sivaprakasam P, Tosso PN, Doerksen RJ.  Structure-activity relationship and comparative docking studies for cycloguanil analogs as PfDHFR-TS inhibitors.  J Chem Inf Model. 2009 Jul;49(7):1787-96.  PMID: 19588935 (JI Project 6 - Doerksen)

Vaka SR, Sammeta SM, Day LB, Murthy SN. Delivery of nerve growth factor to brain via intranasal administration and enhancement of brain uptake. J Pharm Sci 2009 Oct;98(10):3640-6. PMID: 19156912 (JI Project 7 - Murthy)

Wahba AE, Peng J, Kudrimoti S, Tekwani BL, Hamann MT.  Structure-activity relationship studies of manzamine A: amidation of positions 6 and 8 of the beta-carboline moiety.  Bioorg Med Chem. 2009 Nov 15;17(22):7775-82. Epub 2009 Sep 19.  PMID: 19833520 (Chemistry Core)

Wallingford N, Perroud B, Gao Q, Coppola A, Gyengesi E, Liu ZW, Gao XB, Diament A, Haus KA, Shariat-Madar Z, Mahdi F, Wardlaw SL, Schmaier AH, Warden CH, Diano S. Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents. J Clin Invest. 2009 Aug;119(8):2291-303. doi: 10.1172/JCI37209. Epub  2009 Jul 20. PMID: 19620781 (Small Grant - Shariat-Madar)

Xie A, Odde S, Prasanna S, Doerksen RJ.  Imidazole-containing farnesyltransferase inhibitors: 3D quantitative structure-activity relationships and molecular docking.  J Comput Aided Mol Des. 2009 Jul;23(7):431-48. Epub 2009 May 29.  PMID: 19479325 (Small Grant - Doerksen)

Xie A, Clark SR, Prasanna S, Doerksen RJ.  Three-dimensional quantitative structure-farnesyltransferase inhibition analysis for some diaminobenzophenones.  J Enzyme Inhib Med Chem. 2009 Dec;24(6):1220-8.  PMID: 19912055 (JI Project 6 - Doerksen)

Zhang SQ, Rahman Z, Thumma S, Repka MA, Chen GH, Li SM. Development and evaluation of a pH-dependent sustained release tablet for irritable bowel syndrome. Drug Dev Ind Pharm 2009 Jan;35(1):57-64. PMID: 19031287 (JI Project 2 - Repka/Majumdar)

2008 Publications: (* = Recently Added To List)

Agnihotri VK, Elsohly HN, Khan SI, Smillie TJ, Khan IA, Walker LA. Antioxidant constituents of Nymphaea caerulea flowers. Phytochemistry 2008 Jul;69(10):2061-6. Epub 2008 Jun 3. PMID: 18534639 (Sourcing, Acquisition and Isolation Core)

Agnihotri VK, Elsohly HN, Smillie TJ, Khan IA, Walker LA. New Labdane Diterpenes from Leonurus cardiaca. Planta Med 2008 Aug;74(10):1288-90. PMID: 18666048 (Sourcing, Acquisition and Isolation Core)

Ahmed SA, Ross SA, Slade D, Radwan MM, Khan IA, Elsohly MA.  Structure determination and absolute configuration of cannabichromanone derivatives from high potency Cannabis sativa.  Tetrahedron Lett 2008 Oct 13;49(42):6050-6053. PMID: 19844597 (JI Project 3 - Ross; Sourcing, Acquisition and Isolation Core)

Bowling JJ, Pennaka HK, Ivey K, Wahyuono S, Kelly M, Schinazi RF, Valeriote FA, Graves DE, Hamann MT. Antiviral and anticancer optimization studies of the DNA-binding marine natural product aaptamine. Chem Biol Drug Des 2008 Mar;71(3): 205-15. PMID: 18251774 (Chemistry Core)

Boyer EW, Babu KM, Adkins JE, McCurdy CR, Halpern JH. Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth). Addiction 2008 Jun;103(6):1048-50. PMID: 18482427 (JI Project 1 - McCurdy)

Diers JA, Ivey KD, El-Alfy A, Shaikh J, Wang J, Kochanowska AJ, Stoker JF, Hamann MT, Matsumoto RR. Identification of antidepressant drug leads through the evaluation of marine natural products with neuropsychiatric pharmacophores. Pharmacol Biochem Behav 2008 Mar;89(1):46-53. Epub 2007 Nov 6. PMID: 18037479 ( In Vivo Pharmacology Core)

Donia MS, Wang B, Dunbar DC, Desai PV, Patny A, Avery M, Hamann MT. Mollamides B and C, Cyclic hexapeptides from the indonesian tunicate Didemnum molle. J Nat Prod 2008 Jun;71(6):941-5. Epub 2008 Jun 11. PMID: 18543965 (Chemistry Core)

Karamyan VT, Speth RC. Animal models of BMAA neurotoxicity: a critical review. Life Sci 2008 Jan 30;82(5-6):233-46. Epub 2007 Dec 7. PMID: 18191417 (In Vitro Pharmacology Core)

Kochanowska AJ, Rao KV, Childress S, El-Alfy A, Matsumoto RR, Kelly M, Stewart GS, Sufka KJ, Hamann MT. Secondary metabolites from three Florida sponges with antidepressant activity. J Nat Prod 2008 Feb;71(2):186-9. Epub 2008 Jan 25. PMID: 18217716 (In Vivo Pharmacology Core; Chemistry Core)

Mallela J, Perkins R, Yang J, Pedigo S, Rimoldi JM, Shariat-Madar Z, The functional importance of the N-terminal region of human prolylcarboxypeptidase. Biochem Biophys Res Commun 2008 Oct 3;374(4):635-40. Epub 2008 Jul 25. PMID: 18656443 (Small Grant - Shariat-Madar; Chemistry Core)

Mesangeau C, Narayanan S, Green AM, Shaikh J, Kaushal N, Viard E, Xu YT, Fishback JA, Poupaert JH, Matsumoto RR, McCurdy CR. Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity. J Med Chem 2008 Mar 13;51(5):1482-6. Epub 2008 Feb 16. PMID: 18278854 (JI Project 1 - McCurdy)

Radwan MM, Ross SA, Slade D, Ahmed SA, Zulfiqar F, Elsohly MA. Isolation and characterization of new Cannabis constituents from a high potency variety. Planta Med 2008 Feb;74(3):267-72. Epub 2008 Feb 18. PMID: 18283614 (JI Project 3 - Ross)

Radwan MM, Elsohly MA, Slade D, Ahmed SA, Wilson L, El-Alfy AT, Khan IA, Ross SA. Non-cannabinoid constituents from a high potency Cannabis sativa variety. Phytochemistry 2008 Oct;69(14):2627-33. Epub 2008 Sep 4. PMID: 18774146 (JI Project 3 - Ross; Sourcing, Acquisition and Isolation Core; In Vivo Pharmacology Core)

Rahman Z, Kohli K, Zhang SQ, Khar RK, Ali M, Charoo NA, Tauseef M, Shamsher AA, Mohammed NN, Repka MA. In-vivo evaluation in rats of colon-specific microspheres containing 5-fluorouracil. J Pharm Pharmacol 2008 May;60(5):615-23. PMID: 18416938 (JI Project 2 - Repka/Majumdar)

Rao KV, Na MK, Cook JC, Peng J, Matsumoto R, Hamann MT. Kahalalides V-Y isolated from a Hawaiian collection of the sacoglossan mollusk Elysia rufescens. J Nat Prod. 2008 May;71(5):772-8. Epub 2008 Apr 12. PMID: 18355032 (Chemistry Core) *

Repka MA, Majumdar S, Kumar Battu S, Srirangam R, Upadhye SB. Applications of hot-melt extrusion for drug delivery. Expert Opin Drug Deliv 2008 Dec;5(12):1357-76. PMID: 19040397 (JI Project 2 - Repka/Majumdar)

Rumalla CS, Jadhav AN, Smillie T, Fronczek FR, Khan IA. Alkaloids from Heimia salicifolia. Phytochemistry 2008 May;69(8):1756-62. Epub 2008 Mar 28. PMID: 18374955 (Sourcing, Acquisition and Isolation Core)

Shilabin AG, Kasanah N, Tekwani BL, Hamann MT. Kinetic studies and bioactivity of potential manzamine prodrugs. J Nat Prod 2008 Jul;71(7):1218-21. Epub 2008 Jul 4. PMID: 18598080 (Chemistry Core)

Speth RC, Karamyan VT. Brain angiotensin receptors and binding proteins. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377(4-6):283-93. Epub 2008 Jan 3. Review. PMID: 18172611 (In Vitro Pharmacology Core) *

Speth RC, Karamyan VT. The significance of brain aminopeptidases in the regulation of the actions of angiotensin peptides in the brain. Heart Fail Rev. 2008 Sep;13(3):299-309. Epub 2008 Jan 9. Review. PMID: 18188697 (In Vitro Pharmacology Core) *

Thumma S, Majumdar S, ElSohly MA, Gul W, Repka MA. Chemical stability and bioadhesive properties of an ester prodrug of Delta 9-tetrahydrocannabinol in poly(ethylene oxide) matrices: effect of formulation additives. Int J Pharm 2008 Oct 1;362(1-2):126-32. Epub 2008 Jul 5. PMID: 18652884 (JI Project 2 - Repka/Majumdar)

Thumma S, Elsohly MA, Zhang SQ, Gul W, Repka MA. Influence of plasticizers on the stability and release of a prodrug of Delta(9)-tetrahydrocannabinol incorporated in poly (ethylene oxide) matrices. Eur J Pharm Biopharm 2008 Oct;70(2):605-14. Epub 2008 Jun 18. PMID: 18602993 (JI Project 2 - Repka/Majumdar)

Thumma S, Majumdar S, Elsohly MA, Gul W, Repka MA. Preformulation studies of a prodrug of Delta9-tetrahydrocannabinol. AAPS PharmSciTech 2008;9(3):982-90. Epub 2008 Aug 28. PMID: 18756377 (JI Project 2 - Repka/Majumdar)

Tumuluri VS, Kemper MS, Lewis IR, Prodduturi S, Majumdar S, Avery BA, Repka MA. Off-line and on-line measurements of drug-loaded hot-melt extruded films using Raman spectroscopy. Int J Pharm 2008 Jun 5;357(1-2):77-84. Epub 2008 Feb 2. PMID: 18316165 (JI Project 2 - Repka/Majumdar)

2007 Publications:

Battu SK, Repka MA, Majumdar S, Madhusudan RY. Formulation and evaluation of rapidly disintegrating fenoverine tablets: effect of superdisintegrants. Drug Dev Ind Pharm 2007 Nov;33(11):1225-32. PMID: 18058319 (JI Project 2 - Repka/Majumdar)

Bikbulatov RV, Yan F, Roth BL, Zjawiony JK. Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B. Bioorg Med Chem Lett 2007 Apr 15;17(8):2229-32. Epub 2007 Feb 2. PMID: 17303418 (Chemistry Core)

Crowley MM, Zhang F, Repka MA, Thumma S, Upadhye SB, Battu SK, McGinity JW, Martin C. Pharmaceutical applications of hot-melt extrusion: part I. Drug Dev Ind Pharm 2007 Sep;33(9):909-26. PMID: 17891577 (JI Project 2 - Repka/Majumdar)

Giner JL, Kiemle DJ, Kutrzeba L, Zjawiony J. Unambiguous NMR spectral assignments of salvinorin A. Magn Reson Chem 2007 Apr;45(4):351-4. PMID: 17351976 (Chemistry Core)

Hamann MT, Hill R, Roggo S, Marine Natural Products.  Key Advances to the Practical Application of this Resource in Drug Development, Natural Products in Drug Discovery, CHIMIA, 61, No.6, 2007 (ISSN 0009-4293)

Kutrzeba L, Dayan FE, Howell J, Feng J, Giner JL, Zjawiony JK. Biosynthesis of salvinorin A proceeds via the deoxyxylulose phosphate pathway. Phytochemistry 2007 Jul;68(14):1872-81. Epub 2007 Jun 14. PMID: 17574635 (Chemistry Core)

Submitted Publications:

Adkins JE, Moraes NV, White NW, Tadlock LA, Nieto MJ, Avery BA, McCurdy CR.  Analytical HPLC method validation for the identification of the indole alkaloid mitragynine, from extracts of Mitragyna specios.,  Phytochemical analysis (SUBMITTED 2008)