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2009 Publications: Kim, J. K.; Anderson, J.; Jun, H. W.; Repka, M. A.; Jo, S., Self-assembling peptide amphiphile-based nanofiber gel for bioresponsive cisplatin delivery. Mol Pharm 2009, 6, (3), 978-85. Liu, Y.; Veena, C. K.; Morgan, J. B.; Mohammed, K. A.; Jekabsons, M. B.; Nagle, D. G.; Zhou, Y. D., Methylalpinumisoflavone inhibits hypoxia-inducible factor-1 (HIF-1) activation by simultaneously targeting multiple pathways. J Biol Chem 2009, 284, (9), 5859-68. Majumdar, S.; Srirangam, R., Solubility, stability, physicochemical characteristics and in vitro ocular tissue permeability of hesperidin: a natural bioflavonoid. Pharm Res 2009, 26, (5), 1217-25. Majumdar, S.; Hingorani, T.; Srirangam, R.; Gadepalli, R. S.; Rimoldi, J. M.; Repka, M. A., Transcorneal permeation of L: - and d: -aspartate ester prodrugs of acyclovir: delineation of passive diffusion versus transporter involvement. Pharm Res 2009, 26, (5), 1261-9. Ngo, M. L.; Mahdi, F.; Kolte, D.; Shariat-Madar, Z., Upregulation of prolylcarboxypeptidase (PRCP) in lipopolysaccharide (LPS) treated endothelium promotes inflammation. J Inflamm (Lond) 2009, 6, 3. Prasanna, S.; Daga, P. R.; Xie, A.; Doerksen, R. J., Glycogen synthase kinase-3 inhibition by 3-anilino-4-phenylmaleimides: insights from 3D-QSAR and docking. J Comput Aided Mol Des 2009, 23, (2), 113-27. Prasanna, S.; Doerksen, R. J., Topological polar surface area: a useful descriptor in 2D-QSAR. Curr Med Chem 2009, 16, (1), 21-41. Radwan, M. M.; Elsohly, M. A.; Slade, D.; Ahmed, S. A.; Khan, I. A.; Ross, S. A., Biologically Active Cannabinoids from High-Potency Cannabis sativa. J Nat Prod 2009. Vaka, S. R.; Sammeta, S. M.; Day, L. B.; Murthy, S. N., Delivery of nerve growth factor to brain via intranasal administration and enhancement of brain uptake. J Pharm Sci 2009. Zhang, S. Q.; Rahman, Z.; Thumma, S.; Repka, M. A.; Chen, G. H.; Li, S. M., Development and evaluation of a pH-dependent sustained release tablet for irritable bowel syndrome. Drug Dev Ind Pharm 2009, 35, (1), 57-64.
2008 Publications: Adkins, J.E.; Moraes, N.V.; White, N.W.; Tadlock, L.A.; Nieto, M.J.; Avery, B.A.; McCurdy, C.R., Analytical HPLC method validation for the identification of the indole alkaloid mitragynine, from extracts of Mitragyna specios., Phytochemical analysis (SUBMITTED) Agnihotri, V. K.; Elsohly, H. N.; Khan, S. I.; Smillie, T. J.; Khan, I. A.; Walker, L. A., Antioxidant constituents of Nymphaea caerulea flowers. Phytochemistry 2008, 69, (10), 2061-6. Agnihotri, V. K.; Elsohly, H. N.; Smillie, T. J.; Khan, I. A.; Walker, L. A., New Labdane Diterpenes from Leonurus cardiaca. Planta Med 2008. Ahmed, S. A.; Ross, S. A.; Slade, D.; Radwan, M. M.; Zulfiqar, F.; Elsohly, M. A., Cannabinoid ester constituents from high-potency Cannabis sativa. J Nat Prod 2008, 71, (4), 536-42. Bowling, J. J.; Pennaka, H. K.; Ivey, K.; Wahyuono, S.; Kelly, M.; Schinazi, R. F.; Valeriote, F. A.; Graves, D. E.; Hamann, M. T., Antiviral and anticancer optimization studies of the DNA-binding marine natural product aaptamine. Chem Biol Drug Des 2008, 71, (3), 205-15. Boyer, E. W.; Babu, K. M.; Adkins, J. E.; McCurdy, C. R.; Halpern, J. H., Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth). Addiction 2008, 103, (6), 1048-50. Diers, J. A.; Ivey, K. D.; El-Alfy, A.; Shaikh, J.; Wang, J.; Kochanowska, A. J.; Stoker, J. F.; Hamann, M. T.; Matsumoto, R. R., Identification of antidepressant drug leads through the evaluation of marine natural products with neuropsychiatric pharmacophores. Pharmacol Biochem Behav 2008, 89, (1), 46-53. Donia, M. S.; Wang, B.; Dunbar, D. C.; Desai, P. V.; Patny, A.; Avery, M.; Hamann, M. T., Mollamides B and C, Cyclic hexapeptides from the indonesian tunicate Didemnum molle. J Nat Prod 2008, 71, (6), 941-5. Ibrahim, M. A.; Shilabin, A. G.; Prasanna, S.; Jacob, M.; Khan, S. I.; Doerksen, R. J.; Hamann, M. T., 2-N-Methyl modifications and SAR studies of manzamine A. Bioorg Med Chem 2008, 16, (14), 6702-6. Karamyan, V. T.; Speth, R. C., Animal models of BMAA neurotoxicity: a critical review. Life Sci 2008, 82, (5-6), 233-46. Kochanowska, A. J.; Rao, K. V.; Childress, S.; El-Alfy, A.; Matsumoto, R. R.; Kelly, M.; Stewart, G. S.; Sufka, K. J.; Hamann, M. T., Secondary metabolites from three Florida sponges with antidepressant activity. J Nat Prod 2008, 71, (2), 186-9. Mallela, J.; Yang, J.; Shariat-Madar, Z., Prolylcarboxypeptidase: A cardioprotective enzyme. Int J Biochem Cell Biol 2008. Mallela, J.; Perkins, R.; Yang, J.; Pedigo, S.; Rimoldi, J. M.; Shariat-Madar, Z., The functional importance of the N-terminal region of human prolylcarboxypeptidase. Biochem Biophys Res Commun 2008, 374, (4), 635-40. Mesangeau, C.; Narayanan, S.; Green, A. M.; Shaikh, J.; Kaushal, N.; Viard, E.; Xu, Y. T.; Fishback, J. A.; Poupaert, J. H.; Matsumoto, R. R.; McCurdy, C. R., Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity. J Med Chem 2008, 51, (5), 1482-6. Peng, J.; Kudrimoti, S.; Prasanna, S.; Odde, S.; Doerksen, R. J.; Pennaka, H. K.; Choo, Y.; Rao, K. V.; Tekwani, B. L.; Shilabin, A. G.; Mayer, A. M. S.; Jacob, M. R.; Tu, L. C. T.; Gertsch, J.; Hamann, M. T., Structure Activity Relationship and Mechanism of Action Studies of Manzamine Analogues for the Control of Malaria and Neuroinflammation. Journal of the American Chemical Society (SUBMITTED) Radwan, M. M.; Ross, S. A.; Slade, D.; Ahmed, S. A.; Zulfiqar, F.; Elsohly, M. A., Isolation and characterization of new Cannabis constituents from a high potency variety. Planta Med 2008, 74, (3), 267-72. Radwan, M. M.; Elsohly, M. A.; Slade, D.; Ahmed, S. A.; Wilson, L.; El-Alfy, A. T.; Khan, I. A.; Ross, S. A., Non-cannabinoid constituents from a high potency Cannabis sativa variety. Phytochemistry 2008, 69, (14), 2627-33. Rahman, Z.; Kohli, K.; Zhang, S. Q.; Khar, R. K.; Ali, M.; Charoo, N. A.; Tauseef, M.; Shamsher, A. A.; Mohammed, N. N.; Repka, M. A., In-vivo evaluation in rats of colon-specific microspheres containing 5-fluorouracil. J Pharm Pharmacol 2008, 60, (5), 615-23. Repka, M. A.; Majumdar, S.; Kumar Battu, S.; Srirangam, R.; Upadhye, S. B., Applications of hot-melt extrusion for drug delivery. Expert Opin Drug Deliv 2008, 5, (12), 1357-76. Rumalla, C. S.; Jadhav, A. N.; Smillie, T.; Fronczek, F. R.; Khan, I. A., Alkaloids from Heimia salicifolia. Phytochemistry 2008, 69, (8), 1756-62. Shilabin, A. G.; Kasanah, N.; Tekwani, B. L.; Hamann, M. T., Kinetic studies and bioactivity of potential manzamine prodrugs. J Nat Prod 2008, 71, (7), 1218-21. Singh, N.; Nolan, T. L.; McCurdy, C. R., Chemical function-based pharmacophore development for novel, selective kappa opioid receptor agonists. J Mol Graph Model 2008, 27, (2), 131-9. Thumma, S.; Majumdar, S.; ElSohly, M. A.; Gul, W.; Repka, M. A., Chemical stability and bioadhesive properties of an ester prodrug of Delta 9-tetrahydrocannabinol in poly(ethylene oxide) matrices: effect of formulation additives. Int J Pharm 2008, 362, (1-2), 126-32. Thumma, S.; Elsohly, M. A.; Zhang, S. Q.; Gul, W.; Repka, M. A., Influence of plasticizers on the stability and release of a prodrug of Delta(9)-tetrahydrocannabinol incorporated in poly (ethylene oxide) matrices. Eur J Pharm Biopharm 2008. Thumma, S.; Majumdar, S.; Elsohly, M. A.; Gul, W.; Repka, M. A., Preformulation studies of a prodrug of Delta9-tetrahydrocannabinol. AAPS PharmSciTech 2008, 9, (3), 982-90. Tumuluri, V. S.; Kemper, M. S.; Lewis, I. R.; Prodduturi, S.; Majumdar, S.; Avery, B. A.; Repka, M. A., Off-line and on-line measurements of drug-loaded hot-melt extruded films using Raman spectroscopy. Int J Pharm 2008, 357, (1-2), 77-84. Zhang, S. Q.; Thumma, S.; Chen, G. H.; Deng, W. B.; Repka, M. A.; Li, S. M., In vitro and in vivo evaluation of tegaserod maleate pH-dependent tablets. Eur J Pharm Biopharm 2008, 69, (1), 247-54.
2007 Publications: Battu, S. K.; Repka, M. A.; Majumdar, S.; Madhusudan, R. Y., Formulation and evaluation of rapidly disintegrating fenoverine tablets: effect of superdisintegrants. Drug Dev Ind Pharm 2007, 33, (11), 1225-32. Bikbulatov, R. V.; Yan, F.; Roth, B. L.; Zjawiony, J. K., Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B. Bioorg Med Chem Lett 2007, 17, (8), 2229-32. Crowley, M. M.; Zhang, F.; Repka, M. A.; Thumma, S.; Upadhye, S. B.; Battu, S. K.; McGinity, J. W.; Martin, C., Pharmaceutical applications of hot-melt extrusion: part I. Drug Dev Ind Pharm 2007, 33, (9), 909-26. Giner, J. L.; Kiemle, D. J.; Kutrzeba, L.; Zjawiony, J., Unambiguous NMR spectral assignments of salvinorin A. Magn Reson Chem 2007, 45, (4), 351-4. Hamann MT, Hill R, Roggo S, Marine Natural Products. Key Advances to the Practical Application of this Resource in Drug Development, Natural Products in Drug Discovery, CHIMIA, 61, No.6, 2007 (ISSN 0009-4293) Kutrzeba, L.; Dayan, F. E.; Howell, J.; Feng, J.; Giner, J. L.; Zjawiony, J. K., Biosynthesis of salvinorin A proceeds via the deoxyxylulose phosphate pathway. Phytochemistry 2007, 68, (14), 1872-81. Repka, M. A.; Battu, S. K.; Upadhye, S. B.; Thumma, S.; Crowley, M. M.; Zhang, F.; Martin, C.; McGinity, J. W., Pharmaceutical applications of hot-melt extrusion: Part II. Drug Dev Ind Pharm 2007, 33, (10), 1043-57. |
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The Center of Research Excellence in Natural Products Neuroscience (CORE-NPN) is funded by the National Center for Research Resources (NCRR) at the National Institutes of Health (NIH) as one of its Centers of Biomedical Research Excellence |
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