Overview of Core
The Chemistry and DMPK Core (Core B) is designed to provide lead optimization, analytical expertise, drug metabolism and pharmacokinetic data on natural products and related compounds that are determined by CORE-NPN investigators to have significant biological activity in the In Vitro (Core C) and In Vivo (Core D) Cores. In addition, the Chemistry and DMPK Core will make available the bulk-synthesis of compounds that have potential clinical usefulness. The Chemistry and DMPK Core will also have an advisory role for individual projects and other CORE-NPN investigators that require expertise in the area of exploration of structure-activity relationships, analytical method development and validation, chemical modifications to influence pharmacokinetic and metabolism properties, and pharmaceutical and chemical influences on solubility and formulation.
Synthesis Workflow DMPK Workflow