Readings from Molecular Biology of the Cell, Fifth edition.
Alberts, Johnson, Lewis, Raff, Roberts and Walter.
Garland Science Publishing. ISBN-10: 0815341059
| Cl | Day | Date | Topic | Reading | Presentation |
|---|---|---|---|---|---|
| 1 | Mon | 24.Aug | Cells and Genomes | Ch 1 | |
| 2 | Wed | 26.Aug | |||
| 3 | Fri | 28.Aug | Online Resources | MM turnbaugh09GutMicrobiome.pdf | |
| 4 | Mon | 31.Aug | Chem Review | Ch 2 | PS01 due |
| 5 | Wed | 02.Sep | Proteins Review | Ch 3 | |
| 6 | Fri | 04.Sep | DNA and Chromosomes | Ch 4 | |
| Mon | 07.Sep | LABOR DAY HOLIDAY | |||
| 7 | Wed | 09.Sep | |||
| 8 | Fri | 11.Sep | "Kelty, Wallace" | 1 | |
| 9 | Mon | 14.Sep | DNA Replication Repair and Recombination | Ch 5 | |
| 10 | Wed | 16.Sep | |||
| 11 | Fri | 18.Sep | 2 | ||
| 12 | Mon | 21.Sep | Transcription and Translation | Ch 6 | |
| 13 | Wed | 23.Sep | RNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes Kira Glover-Cutter1,3, Soojin Kim1,3, Joaquin Espinosa2 & David L Bentley Nature Structural & Molecular Biology 15, 71 - 78 (2008) | Pubmed | doi:10.1038/nsmb1352 | PDF |
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| 14 | Fri | 25.Sep | |||
| 15 | Mon | 28.Sep | Corey, Jeanie | P3-Corey, Jeanie | PS04 due (PDF | Doc) | |
| 16 | Wed | 30.Sep | Control of Gene expression | Ch 7 | |
| 17 | Fri | 02.Oct | Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein Charnay et al Retrovirology. 2009; 6: 74. Published online 2009 August 11. doi: 10.1186/1742-4690-6-74. PMCID: PMC2739156 | P4-Binh, Lauren | |
| 18 | Mon | 05.Oct | Cell Signalling | Ch 15 | |
| 19 | Wed | 07.Oct | |||
| 20 | Fri | 09.Oct | P5-Charlie, Heather | ||
| 21 | Mon | 12.Oct | Cytoskeleton (Recent Refs) | Ch 16 | |
| 22 | Wed | 14.Oct | Structural Plasticity in Actin and Tubulin Polymer Dynamics | The Dam1 ring binds microtubules strongly enough to be a processive as well as energy-efficient coupler for chromosome motion | ||
| 23 | Fri | 16.Oct | "Terrence, Tochukwu" | 6 | |
| 24 | Mon | 19.Oct | Cell Cycle | Ch 17 | |
| 25 | Wed | 21.Oct | Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution Liam J. Holt,Tuch,VillŽn,Johnson,Gygi and Morgan SCIENCE (2009) VOL 325 p 1682. Abstract Supporting Material | ||
| 26 | Fri | 23.Oct | "Kane, Tabitha" | 7 | |
| 27 | Mon | 26.Oct | Apoptosis | Ch 18 | PS06 due (PDF | Doc) |
| 28 | Wed | 28.Oct | Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis. Allan LA, Clarke PR. Mol Cell. 2007 Apr 27;26(2):301-10. http://dx.doi.org/10.1016/j.molcel.2007.03.019 | ||
| 29 | Fri | 30.Oct | "Brandon, John Paul" | PS07 due (PDF | Doc) | |
| 30 | Mon | 02.Nov | Cancer | Ch 20 | |
| 31 | Wed | 04.Nov | Trim24 targets endogenous p53 for degradation. Allton et al doi: 10.1073/pnas.0813177106 Commentary: TRIMming p53 for ubiquitination | ||
| 32 | Fri | 06.Nov | "Bin, Amanda" | PS08 due (PDF | Doc) | |
| 33 | Mon | 09.Nov | A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3964-9 | Ch 22 | |
| 34 | Wed | 11.Nov | Jasmine, Wyatt | ||
| 35 | Fri | 13.Nov | 10 | ||
| 36 | Mon | 16.Nov | Stem Cells | Ch 23 | Chapter 23 (PDF 6.8 Mb) |
| 37 | Wed | 18.Nov | |||
| 38 | Fri | 20.Nov | Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy Science p326 p818 (2009) PDF
ALD (OMIM Entry) was dramatized in the 1992 film Lorenzo's Oil Movie Trailer | A Real-Life Sequel | ||
| M-F | 23-27 Nov | FALL BREAK | |||
| 39 | Mon | 30.Nov | Proposal | ||
| 40 | Wed | 02.Dec | Peer | ||
| 41 | Fri | 04.Dec | Review | ||
| Mon | 07.Dec | Final Proposal Due by noon |