Chem 580 Schedule Fall 2008

Readings from Molecular Biology of the Cell, Fifth edition.
Alberts, Johnson, Lewis, Raff, Roberts and Walter.
Garland Science Publishing. ISBN-10: 0815341059

Cl Day Date Topic Reading Presentation
1 Mon 25-Aug Cells and Genomes Ch 1
2 Wed 27-Aug
3 Fri 29-Aug MM
Mon 01-Sep LABOR DAY HOLIDAY
4 Wed 03-Sep Proteins Review Ch 3 PS1 (PDF | DOC)
5 Fri 05-Sep
Commentary: A folding space odyssey Davidson
Transitive homology-guided structural studies lead to discovery of Cro proteins with 40% sequence identity but different folds Roessler et al.. Supplement
1 - JD, MG, MD
6 Mon 08-Sep DNA and Chromosomes Ch 4
7 Wed 10-Sep PS2 (PDF | DOC
8 Fri 12-Sep Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation. Chambers et al. 2- BR,EA,JW
9 Mon 15-Sep DNA Replication Repair and Recombination Ch 5
10 Wed 17-Sep PS3 (PDF | DOC
11 Fri 19-Sep AIDS/HIV: A Reversal of Fortune in HIV-1 Integration Engelman, Alan Science 29 June 2007 316: 1855-1857 DOI: 10.1126/science.1145015

HIV-1 Proviral DNA Excision Using an Evolved Recombinase Sarkar,I Hauber,I Hauber,J and Buchholz, Science (2007) 316:1912-1915 DOI: 10.1126/science.1141453
AWS, MAL, LLS
12 Mon 22-Sep Transcription and Translation Ch 6
13 Wed 24-Sep
14 Fri 26-Sep NO CLASS - PRESIDENTIAL DEBATE 4- RATHY
15 Mon 29-Sep Control of Gene expression Ch 7
16 Wed 01-Oct PS4 (PDF | DOC
17 Fri 03-Oct Posttranscriptional Gene Regulation by Spatial Rearrangement of the 3' Untranslated Region. Eberle, Stalder, Mathys, Orozco, Muhlemann. http://dx.doi.org/10.1371/journal.pbio.0060092 5- IK
18 Mon 06-Oct Control of Gene expression Ch 7
19 Wed 08-Oct PS5 (PDF | DOC
20 Fri 10-Oct

RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Ge, McManus, Nguyen, Shen, Sharp, Eisen, and Chen.
PNAS March 4, 2003 vol. 100 no. 5 2718-2723 Figures Only | Full Text | (PDF) | Supporting Table

LH,CU,IU
21 Mon 13-Oct Cell Signalling Ch 15
22 Wed 15-Oct
23 Fri 17-Oct AL, JT, DW
24 Mon 20-Oct Cytoskeleton Ch 16
25 Wed 22-Oct
26 Fri 24-Oct CG, SW, FH
27 Mon 27-Oct Cell Cycle Ch 17
28 Wed 29-Oct
29 Fri 31-Oct DK,DN,KP
30 Mon 03-Nov Apoptosis Ch 18
31 Wed 05-Nov
32 Fri 07-Nov EK,MP,TW
33 Mon 10-Nov Cancer Ch 20
34 Wed 12-Nov
35 Fri 14-Nov RH,SK,RM
36 Mon 17-Nov
37 Wed 19-Nov Development Ch 22 PH,SP,SS
38 Fri 21-Nov Stem Cells Ch 23 WM,RW,JM
M-F 24-28 Nov FALL BREAK
39 Mon 01-Dec Proposal
40 Wed 03-Dec Peer
41 Fri 05-Dec Review
Tue 09-Dec Final Proposal Due by noon
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