Michael A. Repka, D.D.S., Ph.D.

            Michael A. Repka earned a B.S. in Pharmacy from The University of Texas at Austin College of Pharmacy in 1976 and practiced retail and hospital pharmacy while attending dental school, followed by a Doctor of Dental Surgery (DDS) degree from The University of Texas Dental School at San Antonio in 1981 and practiced general dentistry for twelve years. During this time he was appointed Clinical Assistant Professor at The University of Texas Dental School and Baylor College of Dentistry, and founded a pharmaceutical research and development company that specializes in drug delivery to the oral cavity.  He joined the faculty at The University of Mississippi after receiving his Ph.D. from The University of Texas College of Pharmacy.  His research interests include "trans" systems, including transmucosal, trans-nail and transdermal drug delivery systems.  Many of these systems are directed toward the delivery of poorly soluble drugs via hot-melt extrusion techniques.  Polymeric drug delivery design and stabilization of conventional and novel drug delivery systems for natural product compounds such as THC, is a continued focus of research.
 

RESEARCH PUBLICATIONS:
 

·M. A. Repka, J. O'Haver, C-H See, K. Gutta and M. Munjal, Nail morphology studies as assessments for anychomycois treatment modalities. Int. J. Pharm., 245(1-2),25-36 (2002).

·M. A. Repka, J. W. McGinity,F. Zhang, and J. J. Koleng, Hot-Melt Extrusion Technology, Encyclopedia of Pharmaceutical Technology, Ed: J. Swarbrick and J. Boylan, 2nd  Ed, Marcel Dekker, Inc., NY, February (2002).

·M. A. Repka, S. Prodduturi and S. P. Stodghill, Production and Charaterization of Hot-Melt Extruded Films containing Clotrimazole, (in press, Drug Devel, Ind. Pharm.)

·M. A. Repka and J. W. McGinity, Bioadhesive Properties of Hydroxypropylcellulose Topical Films Produced by Hot-Melt Extrusion, J. Contr. Rel, 70,341-351, (2001).

·M. A. Repka and J. W. McGinity, Influence of Chlorpheniramine Maleate on Topical Films Produced by Hot-Melt Extrusion, Pharm. Dev. Tech., 6(3), 295-302. (2001).

·H, W, McGinity, F. Zhang, M. A. Repka and J. J. Koleng, Hot-Melt Extrusion as a Pharmaceutical Process, American Pharmaceutical Review, 4(2),25-36, (2001).

·M. A. Repka and J. W. McGinity, Physical-Mechanical, Moisture Absorption and Bioadhesive Properties of HPC Hot-Melt Extruded Films, Biomaterials, 21 (14), 1509-1517, (2000).

·M. A. Repka and J. W. McGinity, Influence of Vitamin E TPGS on the Properties of Hydrophilic Films Produced by Hot-Melt Extrusion, Int. J. Pharm. 202 (1-2), 63-70, (2000).

·J. W. McGinity, F. Zhang, M. A. Repka and J. J. Koleng, "Thermal Processing of Pharmaceutical Powders", Pharm Tech Japan, 16(6), 897-913, (2000).

·J. W. McGnity, F. Zhang, M. A. Repka and J. J. Koleng, Hot-Melt Extrusion Technology, Enclyclopedia of Pharmaceutical Technology, Ed: J. Swarbrick and J. Boylan, Vol. 19, pp 203-266, Marcel Dekker, Inc., NY, (2000).

·M. A. Repka, T. G. Gerding, S. L. Repka and J. W. McGinity, Influence of Plasticizers and Drugs on the Physical-Mechanical Properties of Hydroxpropylcellulose Films Prepared by Hot-Melt Extrusion, Drug Devel. Ind. Pharm., 25: 5, 627-635, (1999).

·M. A. Repka, Physical-mechanical and chemical properties of topical films produced by hot-melt extrusion.  The University of Texas at Austin: Austin, Texas, August 20, 2000.

·R. O. Williams, M. K. Barron, and M. A. Repka, Application of co-grinding to formulate a model pMDI suspension, Eur. J. Pharm. Biopharm., 48:2  131-140, (1999).

·R. O. Williams III, M. A. Repka, and Jie Liu, Influence of Propellant Composition on Drug Delivery from a Pressurized Metered-Dose Inhaler, Drug Devel. Ind. Pharm., 24:8  763-770, (1998.

·M. A. Repka and J. W. McGinity, Alginic Acid, Handbook of Pharmaceutical Excipients, Third Edition, American Pharmaceutical Association, November, (1999).

·M. A. Repka, RAU: Back to the Basics, Texas J Acad General Dentistry, July, 1991.
 

PRESENTATIONS AT NATIONAL AND INTERNATIONAL CONFERENCES:
 

·S. Prodduturi, S. P. Stodghill, M. A. Repka.  Drug content and adhesive uniformity of Hot-melt extruded hydroxypropyl cellulose films containing clotrimazole.  AAPSPharmSci Vol. 4, No. 4, Abstract W4177, Toronto (2002).

·S. Prudduturi, S. P. Stodghill, M. A. Repka.  Solid-state characterization of Hot-melt extruded films containing clotrimazole.  AAPSPharmSci Vol. 4, No. 4, Abstract W4152, Toronto (2002).

·M. Munjal, K. Gutta, M. A. Repka. Influence of  &[Delta]9-Tetrahydrocannabinol on the Bioadhesive Properties of Cellulosic Films.  AAPSPharmSci Vol. 4, No. 4, Abstract W4091, Toronto (2002).

·M. Munjal, M. A. Repka.  Effect of Processing Temperature on the Stability of  &[Delta]9-Tetrahydrocannabinol in Klucel Ò Polymer Matrix Systems. AAPSPharmSci Vol. 4, No.4, Abstract W5095, Toronto (2002).

·P. Mididoddi, M. A. Repka.  Release Studies of Lidocaine-Incorporated Cellulosic Films Produced by Hot-Melt Extrusion Technology. AAPSPharmSci Vol. 4, No. 4, Abstract W4143, Toronto  (2002).

·P. Mididoddi, M. A. Repka. Bioadhesive Properties of Hot-Melt Extruded Drug Delivery systems on the Human Nail.  AAPSPharmSci Vol. 4, No. 4, Abstract W4144, Toronto (2002).

·M. A. Repka, J. O'Haver, C-H, See, K. Gutta, M. Munjal.  Human Nail Morphology Studies for the Assessment of Topical Treatment Modalities for Onychomycosis.  AAPSPharmSci Vol. 3, No. 3, Abstract, Denver (2001).

·M. A. Repka, M. Munjal, K. Gutta.  Physical and Chemical Properties of Transmucosal Hydroxypropyl Cellulose and Hydroxypropyl Methylcellulose Films Containing Lidocaine.  AAPSPharmSci Vol. 3, No. 3, Abstract, Denver (2001).

·M. A. Repka, S. Prodduturi.  Bioadhesive and Chemical Properties of Hydroxypropyl Cellulose Hot-Melt Extruded Films Containing Nystatin and Clotrimazole.  AAPSPharmSci Vol. 3, No. 3, Abstract, Denver (2001).

·M. A. Repka and J. W. McGinity, Determination of Bioadhesive Strength in vivo on the Human Epidermis of Hot-Melt Extruded Hydroxypropylcellulose Films.  AAPS PharmSci., Supplement, Volume 2, Indianapolis, November, (2000).

·M. A. Repka and J. W. McGinity, Determination of the Physical-Mechanical Properties and Bioadhesive Strength in vivo of Hot­Melt Extruded Hydrophilic Films, AAPS PharmSci., Supplement, Volume 1, Issue 4, New Orleans, November, (1999).

·M. A. Repka and J. W. McGinity, Influence of Relative Humidity and Various Polymer Additives on Moisture Uptake, Mechanical Properties, and Adhesive Properties of Hydroxypropylcellulose Hot-Melt Extruded Films, 26th International Symposium on Controlled Release of Bioactive Materials, Boston, June, (1999).

·M. A. Repka, R. O. Williams, and M. K. Barron, Co-Processing and its Influence on a Model pMDI Formulation Containing Triamcinolone Acetonide and Pluronic F77, 26th International Symposium on Controlled Release of Bioactive Materials, Boston, June, (1999).

·M. A. Repka and J. W. McGinity, Influence of Relative Humidity and Temperature on Hydroxypropylcellulose Hot-Melt Extruded Films Containing Various Polymer Additives, PharmSci, Volume 1, Number 1, p. S-166, San Francisco, November (1998), Supplement.

·M. A. Repka, R.O. Williams, and M. K. Barron, Influence of Co-grinding Drug and a Polymeric Surfactant on Performance of a Pressurized Metered Dose Inhaler Suspension Formulation, PharmSci, Volume 1, Number 1, p. S-54, San Francisco, November (1998), Supplement.

·M. A Repka, R. O. Williams III, and J. Lie, Influence of Propellant Ratio p134a and p227 on the Drug Delivery of Triamcinolone Acetonide from a MDI, 24th International Symposium on Controlled Release of Bioactive Materials, Controlled Release Society, Stockholm, Sweden, June 15-19, (1997).

·M. A. Repka, T. G. Gerding, S. L. Repka, and J. W. McGinity, Influence of Aging on the Physical/Mechanical Properties of Hydroxypropylcellulose Hot-Melt Extruded Films Incorporated with Plasticizers/Drugs, Pharm. Res., Volume 14, Number 11, Boston, November, (1997), Supplement.

·M. A. Repka, T. G. Gerding, S. L. Repka, and J. W. McGinity, Influence of Plasticizers/Drugs on the Physical-Mechanical Properties of Hydroxypropylcellulose Hot-Melt Extruded Films, Pharm. Res., Volume 13, Number 9, Seattle, September 1996, Supplement.
 

PATENTS:
 

·M. A. Repka, S. L. Repka and J. W. McGinity, Bioadhesive Hot-Melt Extruded Film for Topical and Mucosal Adhesion Applications and Drug Delivery and Process for Preparation Thereof, U. S. Patent, No. 6,375,963,(2002).

·M. A. Repka and T. G. Gerding, Bioadhesive Polyethylene Glycol Ointment for Medicaments, U. S. Patent, No. 5,714,165, (1998).

·M. A. Repka and  T. G. Gerding, Polyethylene Glycol Ointment for Aphthous Ulcers, U. S. Patent, No. 5,112,620, (1992)
 

HONORS AND AWARDS:
 

·American Association of Colleges of Pharmacy, New Investigator Program Grant  (2001-2002)

·Drug Development and Industrial Pharmacy - Editorial Board (2000-present)

·American Foundation for Pharmaceutical Education Pre-doctoral Fellowship (1998-2000)

·Alumnus of the Year - 1992 - University of Texas Dental School at San Antonio

·Medical/Dental Staff Advisor - Tri-City Community Hospital (1982-1989)

·Omicron Kappa Upsilon (Dental Honorary Society), 1981-Present

·Rho Chi (Pharmacy Honorary Society), 1976-Present
                                                                                                                                                           

marepka@olemiss.edu