The chemistry of proanthocyanidins; synthesis of radio labeled precursors for condensed tannin/flavonoid biosynthetic studies; antioxidant activity and mechanism; application of Circular Dichroism in structure elucidation; synthesis/stereoselective synthesis of lead compounds; structure/activity relationship studies; synthesis of A-type proanthocyanidins; synthesis of 8-aminoquinoline-type anti malaria compounds; systematic study of the chemistry/biology of the anti-adherence properties of Cranberry proanthocyanidins in preventing urinary tract infections.