The University of Mississippi School of Pharmacy

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Representative and Refereed Publications

*Denotes Refereed Review

El Sayed, K.A.; Shallal, H.M.; Khanfar, M.; Muralidharan, A; Awate, B.; Youssef, D.T.A.; Liu, Y.; Zhou, Y.-D.; Nagle, D.G.; Shah, G. “Latrunculin A and its 17-O-carbamates inhibit prostate tumor cell invasion and HIF-1 activation in breast tumor cells” J. Nat. Prod. In Press.

Chittiboyina, A.G.; Gundluru, M.K.; Carvalho, P.; Liu, Y.; Zhou, Y.-D.; Nagle, D.G.; Avery, M.A. “Total Synthesis and Absolute Configuration of Laurenditerpenol: A HIF-1 Activation Inhibitor.” J. Med. Chem. 2007, 50, 6299-6302.

Dai, J.; Liu, Y.; Zhou, Y.-D.; Nagle, D.G. “Cytotoxic metabolites from an Indonesian sponge Lendenfeldia sp.” J. Nat. Prod. 2007, 70, 1824–1826.

Liu, Rui; Liu, Yang; Zhou, Y.-D.; Nagle, D.G. “Molecular-targeted antitumor agents 15: Neolamellarins from the marine sponge Dendrilla nigra inhibit hypoxia-inducible factor-1 (HIF-1) activation and secreted vascular endothelial growth factor (VEGF) production in breast tumor cells” J. Nat. Prod. 2007, 70, 1741–1745.

Dai, Jingqiu; Liu, Yang; Jia, Hong; Zhou, Y.-D.; Nagle, D.G. “Benzochromenones from the marine crinoid Comantheria rotula inhibit hypoxia-inducible factor-1 (HIF-1) reporter activity and differentially suppress the growth of certain tumor cell lines” J. Nat. Prod. 2007, 70, 1462-1466.

Dai, J.; Liu, Y.; Zhou, Y.-D.; Nagle, D.G. “Hypoxia-selective antitumor Agents: Norsesterterpene peroxides from the marine sponge Diacarnus levii preferentially suppress the growth of tumor cells under hypoxic conditions” J. Nat. Prod. 2007, 70, 130-133..

Dai, J.; Fishback, J.A.; Zhou, Y.-D.; Nagle, D.G. “Sodwanone and yardenone triterpenes from a South African species of the marine sponge Axinella inhibit hypoxia-inducible factor-1 (HIF-1) Activation in both Breast and Prostate Tumor Cells” J. Nat. Prod. 2006, 69, 1715-1720.

*Nagle, D.G; Ferreira, D.; Zhou, Y.-D. “Molecules of Interest: Epigallocatechin-3-gallate (EGCG): Chemical and Biomedical Perspectives” Phytochemistry 2006, 67, 1849-1855. (The #2 most accessed publication in the journal Phytochemistry for 2006.)

*Nagle, D.G.; Zhou, Y.-D. "Natural Product-Derived Small Molecule Activators of Hypoxia-Inducible Factor-1 (HIF-1)" Curr. Pharm. Design, 2006, 7, 355-369.

Mora, F.D; Jones, D.K.; Desai, P.V.; Patny, A.; Avery, M.A.; Feller, D.R.; Smillie, T.; Zhou, Y.-D.; Nagle, D.G. “Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPAR gamma): The marine sponge metabolite psammaplin A activates PPAR gamma and induces apoptosis in human breast tumor cells” J. Nat. Prod. 2006, 69, 547-552. (Graphical abstract featured in Nat. Prod. Rep. #50944).

Arbiser, J.L.; Govindarajan, B.; Battle, T.; Lynch, R.; Frank, D.A.; Ushio-Fukai, M.; Perry, B.N.; Stern, D.F.; Bowden, G.T.; Liu, A.; Klein, E.; Kolodziejski, P.J.; Eissa, N.T.; Hossain, C.F.; Nagle, D.G. “Carbazole is a naturally occurring inhibitor of angiogenesis and inflammation isolated from antipsoriatic coal tar” J. Invest. Dermatol. 2006, 126, 1396-1402.

*Nagle, D.G.; Zhou, Y-D. "Natural Product-Based Inhibitors of Hypoxia-Inducible Factor-1 (HIF-1)" Curr. Drug Targ. 2006, 7, 355-369.

Li., X.C.; Jacob, M.R.; Ding, Y.; Agarwal, A.K.; Smillie, T.J.; Khan, S.I.; Nagle, D.G.; Ferreira, D.; Clark, A.M. "Capisterones A and B, which enhance fluconazole activity in Saccharomyces cerevisiae from the marine green alga Penicillus capitatus" J. Nat. Prod. 2006, 69, 542-546. (Graphical abstract featured in Nat. Prod. Rep. #50832).

Arbiser, J.L.; Li, X.-C.; Hossain, C.F.; Nagle, D.G.; Smith, D.M.; Miller, P.; Govindarajan, B.; DiCarlo, J.; Landis-Piwowar, K.R.; Dou, Q.P. “Naturally occurring proteasome inhibitors from mate tea (Ilex paraguayensis) serve as models for topical proteasome inhibitors” J. Invest. Dermatol. 2005, 125, 207-212.

Hossain, C.F.; Kim, Y.-P.; Baerson, S.R.; Zhang, L.; Bruick, R.K.; Mohammed, K.A.; Agarwal, A.K.; Nagle, D.G.; Zhou, Y.-D. "Saururus cernuus Lignans - Potent Small Molecule Inhibitors of Hypoxia-Inducible Factor-1” Biochem. Biophys. Res. Comm., 2005, 333, 1026-33.

Zhou, Y.-D.; Kim, Y.-P.; Mohammed, K.A.; Jones, D.K.; Muhammad, I.: Dunbar, D.C.; Nagle, D.G. “The Terpenoid Tetrahydroisoquinoline Alkaloids Emetine, Klugine, and Isocephaeline Inhibit the Activation of Hypoxia-Inducible Factor-1 (HIF-1) in Breast Tumor Cells” J. Nat. Prod., 2005, 68, 947-50.

*Nagle, D.G.; Zhou, Y.-D.; Mora, F.D.; Mohammed, K.A.; Kim, Y.-P. “Mechanism Targeted Discovery of Antitumor Marine Natural Products” Curr. Med. Chem. 2004, 11, 1725-56.

Zhou, Y.-D.; Kim, Y.-P.; Li, X.-C.; Baerson, S.R.; Agarwal, A.K.; Hodges, T.W.; Ferreira, D.; Nagle, D.G. "Hypoxia-inducible factor-1 activation by (-)-epicatechin gallate: Potential adverse effects of cancer chemoprevention with high-dose green tea extracts" J. Nat. Prod. 2004, 67, 2063-9.

Mohammed, K.A.; Hossain, C.F.; Zhang, L.; Bruick, R.K.; Zhou, Y.-D.; Nagle, D.G. "Laurenditerpenol, a new diterpene from the tropical marine alga Laurencia intricata potently inhibits HIF-1 mediated hypoxic signaling in breast tumor cells" J. Nat. Prod. 2004, 67, 2002-7. (Jack L. Beal Award winning manuscript - American Society of Pharmacognosy).

Li, X.-C.; Ferreira, D.; Jacob, M.R.; Zhang, Q.; Khan, S.I.; ElSohly, H.N.; Nagle, D.G.; Smillie, T.J.; Khan, I.A.; Walker, L.A.; Clark, A.M. “Antifungal cyclopentenediones from Piper coruscans” J. Am. Chem. Soc. 2004, 126, 6872-3.

Hodges, T.W.; Hossain,C.F.; Kim, Y.-P. Zhou, Y.-D.; Nagle, D.G. “Molecular-Targeted Antitumor Agents: The Saururus cernuus dineolignans manassantin B and 4-O-demethylmanassantin B are potent inhibitors of hypoxia-activated HIF-1” J. Nat. Prod. 2004, 67, 767-71.

Takamatsu, S.; Nagle, D.G.; Gerwick, W.H. “Secondary metabolites from marine cyanobacteria and algae inhibit LFA-1/ICAM-1-mediated cell adhesion” Planta Medica 2004, 70, 127-31.

Jacob, M.R.; Hossain, C.F.; Mohammed, K.A.; Smillie, T.J.; Clark, A.M., Walker, L.A.; Nagle, D.G. “Reversal of fluconazole resistance in multidrug efflux-resistant fungi by the Dysidea arenaria sponge sterol 9a,11a-epoxycholest-7-ene-3b,5a,6a,19-tetrol 6-acetate” J. Nat. Prod. 2003, 66, 1618-22.

Agarwal, A.; Rogers, P.D.; Baerson, S. R.; Jacob, M.R.; Barker, K.S.; Cleary, J.D.; Walker, L.A.; Nagle, D.G.; Clark, A.M. “Genome-wide expression profiling of the response to polyene, pyrimidine, azole, and echinocandin antifungal agents in Saccharomyces cerevisiae.” J. Biol. Chem. 2003, 278, 34998-5015.

Li, X.-C.; Jacob, M.R.; ElSohly, H.N.; Nagle, D.G.; Smillie, T.J.; Walker, L.A.; Clark, A.M. “Acetylenic Acids Inhibiting Azole-resistant Candida albicans from Pentagonia gigantifolia” J. Nat. Prod. 2003, 68, 1132-5.

Takamatsu, S.; Hodges, T.W.; Gerwick, W.H.; Hamann, M.T.; Nagle, D.G. “Marine natural products as novel antioxidant prototypes” J. Nat. Prod. 2003, 66, 605-8.

Hossain, C.F.; Jacob, M.R.; Clark, A.M.; Walker, L.A; Nagle, D.G. “Genipatriol, a new cycloartane triterpene from Genipa spruceana” J. Nat. Prod. 2003, 66, 398-400.

Nagle, D.G.; Sultana, G.N.N.; Schrader, K.K.; Hossain, C.F.; Stanikunaite, R.; Hamann, M.T.; Rajbandari, I. “Secondary metabolites from plants and marine organisms as selective anti cyanobacterial agents” in Off-flavor in Aquaculture, ACS Symposium Series, A.M. Rimando; K.K. Schrader, eds, American Chemical Society, 2003, 179-94.

*Nagle, D.G.; Slattery, M.S.; Clark, A.M. “Chemical ecology and natural products from wetlands: Emerging perspectives” in Sustainability of Wetlands and Water Resources: Achieving Sustainable Systems in the 21st Century, M.M. Holland; E. Blood; L. Shaffer, eds, Island Press, 2003, 157-69.

*Nagle, D.G.; Wedge, D.E. “Antifungal properties of cyanobacteria and algae: ecological and agricultural implications” in Chemical Ecology of Plants: Allelopathy in Aquatic and Terrestrial Ecosystems, A. Mallik; Inderjit, eds, Birkhauser-Verlag AG, Switzerland, 2002, 7-32.

*Nagle, D.G.; Inderjit “The chemistry and chemical ecology of biologically active cyanobacterial metabolites” in Chemical Ecology of Plants: Allelopathy in Aquatic and Terrestrial Ecosystems, A. Mallik; Inderjit, eds, Birkhauser-Verlag AG, Switzerland, 2002, 33-56.

*Schrader, K.K.; Nagle, D.G.; Wedge, D.E. “Algal and cyanobacterial metabolites as agents for pest management” in Advances in Microbial Toxin Research and its Biotechnological Exploitation, R.K. Upadhyay ed., Kluwer Academic Press, London, 2002, 171-95.

Rajbhandari, I.; Takamatsu, S.; Nagle, D.G. “A new dehydrogeranylgeraniol antioxidant from Saururus cernuus that inhibits intracellular reactive oxygen species (ROS)-catalyzed oxidation within HL-60 cells” J. Nat. Prod. 2001, 63, 693-5.

Nagle, D.G.; Zhou, Y.-D.; Park, P.U.; Paul, V.J.; Rajbhandari, I.; Duncan, C.J.G.; Pasco, D.S. “A new indanone from the marine cyanobacterium Lyngbya majuscula that inhibits hypoxia-induced activation of the VEGF promoter in Hep3B cells” J. Nat. Prod. 2000, 63, 1431-3.

Wedge, D.E.; Nagle, D.G. “A new 2D-TLC bioautography method for the discovery of novel antifungal agents to control plant pathogens” J. Nat. Prod. 2000, 63, 1050-4.

Nagle, D.G.; Paul, V.J. “Production of secondary metabolites by filamentous tropical marine cyanobacteria: ecological functions of the compounds” J. Phycol. 1999, 35, Suppl. 607, 1412-21.

Harrigan, G.G.; Luesch, H.; Yoshida, W.; Moore, R.E.; Nagle, D.G.; Paul, V.J. “Symplostatin 2: A dolastatin 13 analogue from the marine cyanobacterium Symploca hydnoides” J. Nat. Prod. 1999, 62, 655-8.

Harrigan, G.G.; Luesch, H.; Yoshida, W.; Moore, R.E.; Nagle, D.G.; Biggs, J.; Park, P.U.; Paul, V.J. “Tomonoic acids: Novel metabolites from a cyanobacterial assemblage of Lyngbya majuscula and Schizothrix calcicola” J. Nat. Prod. 1999, 62, 464-7.

Harrigan, G.G.; Yoshida, W.; Moore, R.E.; Nagle, D.G.; Park, P.U.; Biggs, J.; Paul, V.J.; Mooberry, S.L.; Corbett, T.H.; Valeriote, F.A. “Isolation, structure determination, and biological activity of dolastatin 12 and lyngbyastatin 1 from Lyngbya majuscula/Schizothrix calcicola cyanobacterial assemblages.” J. Nat. Prod. 1998, 61, 1221-5.

Harrigan, G.G.; Luesch, H.; Yoshida, W.Y.; Moore, R.E.; Nagle, D.G.; Paul, V.J.; Mooberry, S.L.; Corbett, T.H.; Valeriote, F.A. “Symplostatin 1: A dolastatin 10 analog from the marine cyanobacterium, Symploca hydnoides” J. Nat. Prod. 1998, 61, 1075-7.

Nagle, D.G.; Camacho, F.T.; Paul, V.J. “Dietary preferences of the opisthobranch mollusc Stylocheilus longicauda for secondary metabolites produced by the tropical cyanobacterium Lyngbya majuscula” Mar. Biol. 1998, 132, 267-73.

Nagle, D.G.; Paul, V.J. “Chemical defense of a marine cyanobacterial bloom” J. Exp. Mar. Biol. Ecol. 1998, 225, 29-38.

Verdier-Pinard, P.; Lai, J.-Y.; Yoo, H.-D.; Yu, J.; Marquez, B.; Nagle, D.G.; Nambu, M.; White, J.D.; Falck, J.R., Gerwick, W.H.; Day, B.W.; Hamel, E. “Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells” Mol. Pharmcol. 1998, 53, 62-76.

Thacker, R.W.; Nagle, D.G.; Paul, V.J. “Effects of repeated exposures to marine cyanobacterial secondary metabolites on feeding by juvenile rabbitfish and parrotfish” Mar. Ecol. Prog. Ser. 1997, 147, 21-9.

Nagle, D.G.; Park. P.U.; Paul, V.J. “Pitiamide, a new chlorinated lipid from a mixed marine cyanobacterial assemblage” Tetrahedron Lett. 1997, 38, 6969-72.

Nagle, D.G.; Paul, V.J.; M.A. Roberts “Ypaoamide, a new broadly acting antifeedent metabolite from the marine cyanobacterium Lyngbya majuscula” Tetrahedron Lett. 1996, 37, 6263-6.

Nagle, D.G.; Gerwick, W.H. “Nakienones A-C and nakitriol, new cytotoxic cyclic C11 metabolites from an Okinawan microalgal (Synechocystis sp.) overgrowth of coral” Tetrahedron Lett. 1995, 36, 849-52.

Rorrer, G.L.; Modrell, J.; Yoo, H.-D.; Nagle, D.G.; Gerwick, W.H. “Bioreactor seaweed cell culture for biomedicinal production” J. Appl. Phycol. 1995, 7, 187-98.

Hamel, E.; Blokhin, A.V.; Nagle, D.G.; Yoo, H.-D.; Gerwick, W.H. “Limitations in the use of tubulin polymerization assays as a screen for the identification of new antimitotic agents: the potent marine natural product curacin A as an example” Drug Devel. Res. 1995, 34, 110-20.

Orjala, J.; Nagle, D.G.; Gerwick, W.H. “Malyngamide H, an ichthyotoxic amide possessing a new carbon skeleton from the Caribbean cyanobacterium Lyngbya majuscula” J. Nat. Prod. 1995, 58, 764-8.

Orjala, J.; Nagle, D.G.; Hsu, V.L.; Gerwick, W.H. “Antillatoxin: An exceptionally ichthyotoxic cyclic lipopeptide from the tropical cyanobacterium Lyngbya majuscula” J. Am. Chem. Soc. 1995, 117, 8281-2.

Blokhin, A.V.; Yoo, H.-D.; Geralds, R.S; Nagle, D.G.; Gerwick, W.H.; Hamel, E. “Characterization of the interaction of the marine cyanobacterial natural product curacin A with the colchicine site of tubulin and initial structure-activity studies with analogs” Mol. Pharmacol. 1995, 48, 523-31.

Nagle, D.G.; Geralds, R.S.; Yoo, H.-D.; Gerwick, W.H.; Kim, T.-S.; Nambu, M.; White, J.D. “Absolute configuration of curacin A, a novel antimitotic agent from the tropical marine cyanobacterium Lyngbya majuscula” Tetrahedron Lett. 1995, 36, 1189-92.

Nagle, D.G. “Novel oxylipins and other bioactive metabolites from marine algae (antitumor agents, curacin A” Diss. Abstr. Int. B. 1995, 56, 192.

Gerwick, W.H.; Proteau, P.J.; Nagle, D.G.; Hamel, E.; Blokhin, A.; Slate, D.L. “Structure of curacin A, a novel antimitotic, antiproliferative and brine shrimp toxic natural product from the marine cyanobacterium Lyngbya majuscula” J. Org. Chem. 1994, 59, 1243-5.

Nagle, D.G.; Gerwick, W.H. “Structure and stereochemistry of constanolactones A-G, lactonized cyclopropyl oxylipins from the marine red alga Constantinea simplex” J. Org. Chem. 1994, 59, 7227-37.

*Gerwick, W.H.; Proteau, P.J.; Nagle, D.G. “Oxylipins from Marine Invertebrates” in Topics in Current Chemistry, Vol. 167, P.J. Scheuer, ed., Springer-Verlag, Berlin, 1993, 117-80.

*Gerwick, W.H.; Proteau, P.J.; Nagle, D.G.; Wise, M.L.; Jiang, Z.D.; Bernart, M.W.; Hamberg, M. “Biologically active oxylipins from seaweeds” Hydrobiologia 1993, 260/261, 653-65.

*Gerwick, W.H.; Bernart, M.W.; Jiang, Z.D.; Moghaddam, M.F.; Nagle, D.G.; Proteau, P.J.; Wise, M.L.; Hamberg, M. “Patterns of oxylipin metabolism in marine organisms” Vol. I, Dev. Indust. Microbiol. 1993, 369-78.

Nagle, D.G.; McClatchey, W.C.; Gerwick, W.H. “New glycosphingolipids from the marine sponge Halichondria panicea ” J. Nat. Prod. 1992, 55, 1013-7.

*Gerwick, W.H.; Bernart, M.W.; Moghaddam, M.F.; Jiang, Z.D.; Solem, M.L.; Nagle, D.G. “Eicosanoids from the Rhodophyta: a new metabolism in the alga” Hydrobiologia 1990, 204/205, 621-8.

Nagle, D.G.; Gerwick, W.H. “Constanolactones A and B, novel cyclopropyl hydroxy eicosanoids from the temperate red alga Constantinea simplex” Tetrahedron Lett. 1990, 31, 2995 8.