Representative Publications
Nagle, D.G.; Zhou, Y.-D. "Natural
product-derived small molecule activators of hypoxia-inducible factor-1
(HIF-1)" Current
Pharmaceutical Design, In Press.
Nagle, D.G.; Zhou, Y.-D. "Natural product-based inhibitors of
hypoxia-inducible
factor-1 (HIF-1)" Current
Cancer Drug Targets, In Press.
Hossain, C.F.;
Kim, Y.-P.; Baerson, S.R.; Zhang, L.; Bruick, R.K.; Mohammed, K.A.;
Agarwal,
A.K.; Nagle, D.G.; Zhou, Y.-D. "Saururus cernuus lignans - potent
small molecule inhibitors of
hypoxia-inducible factor-1” Biochemical
and Biophysical Research Communications 333,
1026-33, 2005.
Zhou, Y.-D.; Kim,
Y.-P.; Mohammed, K.A.;
Jones, D.K.; Muhammad, I.: Dunbar, D.C.; Nagle, D.G. "The
terpenoid tetrahydroisoquinoline
alkaloids emetine, klugine, and isocephaeline inhibit the activation of
hypoxia-inducible factor-1 (HIF-1) in breast tumor cells"
Journal of Natural Products 68, 947-50, 2005.
Zhou, Y.-D.; Kim,
Y.-P.; Li, X.-C.; Baerson, S.R.; Agarwal, A.K.; Hodges, T.W.; Ferreira,
D.; Nagle,
D.G. "Hypoxia-inducible factor-1
activation by (-)-epicatechin gallate: Potential adverse effects of
cancer
chemoprevention with high-dose green tea extracts"
Journal of Natural Products 67, 2063-9, 2004.
Mohammed, K.A.; Hossain, C.F.; Zhang, L.;
Bruick, R.K.; Zhou, Y.-D.; Nagle, D.G.
"Laurenditerpenol, a new diterpene from
the tropical marine alga Laurencia
intricata potently inhibits HIF-1 mediated hypoxic signaling in
breast
tumor cells" Journal of
Natural Products
67, 2002-7, 2004.
Erbel-Sieler, C.; Dudley, C.; Zhou,
Y.; Wu., X.; Estill, S.J.; Han, T.; Diaz-Arrastia, R.; Brunskill,
E.W.;
Potter, S.S.; McKnight, S.L.
"Behavioral and regulatory abnormalities in mice deficient in
the
NPAS1 and NPAS3 transcription factors"
Proceedings of the National Academy of Sciences USA
101, 13648-53, 2004.
Hodges, T.W.; Hossain, C.F.; Kim, Y.-P.; Zhou, Y.-D.; Nagle, D.G.
"Molecular-targeted antitumor agents: the Saururus
cernuus dineolignans manassantin B and 4-O-demethylmanassantin
B are potent
inhibitors of hypoxia-activated HIF-1"
Journal of Natural Products 67,
767-71, 2004.
Nagle, D.G.; Zhou, Y.-D.;
Mora, F.D.; Mohammed, K.A.; Kim, Y.-P.
"Mechanism targeted discovery of antitumor marine natural
products" Current Medicinal
Chemistry
11, 1725-56, 2004.
Nagle DG, Zhou Y-D, Park PU, Paul VJ, Rajbhandari
I, Duncan CJG, and Pasco DS “A new
indanone from the marine cyanobacterium Lyngbya
majuscula that inhibits hypoxia-induced activation of the VEGF
promoter in
Hep3B cells” Journal of
Natural Products
63, 1431-3, 2000.
Esther CR,
Semeniuk D, Marino EM, Zhou Y,
Overbeek PA, and Bernstein KE
“Expression of testis angiotensin-converting enzyme is mediated
by a
cyclic AMP responsive element” Laboratory
Investigation 77, 483-8, 1997.
Zhou Y-D, Barnard M, Tian H,
Li X, Ring HZ,
Francke U, Shelton J, Richardson J, Russell DW, and McKnight SL “Molecular characterization of two mammalian
bHLH-PAS domain proteins selectively expressed in the central nervous
system” Proceedings of the
National Academy of Sciences
USA 94, 713-8, 1997.
Zhou Y, Sun Z, Means AR,
Sassone-Corsi P, and Bernstein KE “cAMP-response
element modulator tau is a
positive regulator of testis angiotensin converting enzyme transcription” Proceedings
of the National Academy of
Sciences USA 93, 12262-6. 1996.
Esther, C.R.;
Howard, T.E.; Zhou, Y.; Capecchi,
M.R.; Marrero, M.B.; Bernstein,
K.E. “Lessons from angiotensin-converting
enzyme-deficient mice” Current
Opinion in Nephrology and Hypertension 5, 463-7, 1996.
Zhou Y, Overbeek PA, and
Bernstein KE “Tissue specific expression
of testis
angiotensin converting enzyme is not determined by the -32
non-consensus TATA
motif” Biochemical and
Biophysical
Research Communications 223,
48-53, 1996.
Zhou Y, Delafontaine P,
Martin BM, and Bernstein KE “Identification of two positive
transcriptional elements within the 91 base pair promoter for mouse
testis
angiotensin converting enzyme (testis ACE)”
Developmental Genetics 16, 201-9, 1995.
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