Franck E. Dayan determines the molecular sites of action of potential natural herbicides, as well as bioassays compounds isolated by both NCNPR and NPURU chemists.

CURRICULUM VITAE
NAME: Franck E. Dayan

ADDRESS: 
USDA-ARS-NPURU 
P. O. Box 8048 
Natural Products Center 
School of Pharmacy 
University of Mississippi 
University, MS 38677 

PHONE: 662-915-1039 
FAX: 662-915-1035 
E-MAIL: fdayan@olemiss.edu 

EDUCATION 

1992-1995 Ph. D. in Botany with emphasis in Plant Physiology, Auburn University in Auburn, Alabama. 
Dissertation title: Physiological and Biochemical Basis for Tolerance to Sulfentrazone in Soybeans and Selected Weeds. 
1990-1992 M. S. in Biology with emphasis in Plant Physiology and minor in Statistics, Stephen F. Austin State University in Nacogdoches, Texas. 
1986-1988 B.S. in Biology with emphasis in Botany and minor in Chemistry, Stephen F. Austin State University in Nacogdoches, Texas.
1985-1986 Tyler Junior College in Tyler, Texas. 
1981-1984 Valedictorian from Institut Agricole de Fontlongue in Miramas, France. 

PROFESSIONAL EXPERIENCE 

1996-Present Research Plant Physiologist at the USDA,ARS,NPURU in the National Center for the Development of Natural Products, School of Pharmacy of the University of Mississippi. 
1995-1996 Research Plant Physiologist at the USDA-ARS Southern Weed Science Laboratory in Stoneville, Mississippi. 

TEACHING POSITIONS 

1994-1995 Plant Physiology lecture and laboratory, Auburn University. 
1994 Introductory Plant Biology lecture and laboratory, Auburn University. 
1992-1993 Plant Physiology laboratory, Auburn University. 
1990-1991 Introductory Biology and Botany Laboratory, Stephen F. Austin State University. 
Fall 1989 Organic Chemistry Laboratory, Stephen F. Austin State University. 
1988-1989 Technical English to mechanics, and Conversational English to fighter pilots in the French airforce. 

HONORS 

- USDA Certificate of Merit for Research 
- Outstanding Foreign Student Award, Auburn University, 1995. 
- First place in the Graduate Student Research Forum, Auburn University, 1993. 
- Beta Beta Beta Biology Honor Society 
- Gamma Sigma Epsilon Chemistry Honor Society 
- Recipient of the Pepe Romero Classical Guitar scholarship in 1986. 
- Recipient of an Exchange Student Scholarship from Rotary International in 1984. 
- 2001Early Career Scientist of the Year Award (MSA)

MEMBERSHIP IN PROFESSIONAL AND ACADEMIC SOCIETIES 

American Society of Plant Physiologist 
Weed Science Society of America 
Phytochemistry 

LANGUAGES 

French and English written and spoken fluently. 

PUBLICATIONS 
1996
1. Dayan, F. E., Weete, J. D., and Hancock, H. G.  Physiological basis for differential sensitivity to sulfentrazone by sicklepod (Senna obtusifolia) and coffee senna (Cassia occidentalis).  Weed Science, 44, 12-16.  1996.

2. Dayan, F. E., Green, H. M., Weete, J. D., and Hancock, H. G.  Postemergence activity of sulfentrazone:  Effects of surfactants and leaf surfaces.  Weed Science, 44, 797-803.  1996.

3. Dayan, F. E. and Duke, S. O.  Porphyrin-generating herbicides.  Pesticide Outlook, 7, 22-27.  1996.

4. Duke S. O., Dayan, F. E., Yamamoto, M., Duke, M. V., Reddy, K. N., Lee, H. J., Jacobs, N. J., and Jacobs, J. M.  Protoporphyrinogen oxidase inhibitors - Their current and future roles.  Proceedings of the Second International Weed Control Congress.  775-780.  1996.

5. Jacobs, J. M., Jacobs, N. J., Kuhn, C. B., Gorman, N., Dayan, F. E., Duke, S. O., Sinclair, J. F., and Sinclair, P. R.  Oxidation of porphyrinogens by horseradish peroxidase and formation of a green pyrrole pigment.  Biochemical and Biophysical Research Communications, 227, 195-199.  1996.

1997
6. Dayan, F. E., Duke, S. O., Reddy, K. N., Hamper, B. C., and Leschinsky, K. L. Effects of isoxazole herbicides on protoporphyrinogen oxidase and porphyrin physiology.  Journal of Agricultural and Food Chemistry, 45, 967-975.  1997.

7. Dayan, F. E., Weete, J. D., Duke, S. O., and Hancock, H. G.  Soybean (Glycine max) cultivar differences in response to sulfentrazone.  Weed Science, 45, 634-641. 1997.

8. Dayan, F. E., Duke, S. O., Weete, J. D., and Hancock, H. G.  Selectivity and mode of action of carfentrazone-ethyl, a novel phenyl triazolinone herbicide.  Pesticide Science, 51, 65-73.  1997. 

9. Dayan, F. E. and Duke, S. O.  Phytotoxicity of protoporphyrinogen oxidase inhibitors: Phenomenology, mode of action and mechanisms of resistance in Herbicides Activity: Toxicology, Biochemistry and Molecular Biology (Roe, R. M., Burton, J. D. and Kuhr, R. J., eds).  I.O.S. Press, Inc., Amsterdam pages 11-35.  1997.

10. Dayan, F. E. and Duke, S. O.  Overview of protoporphyrinogen oxidase-inhibiting herbicides.  Proceedings of the Brighton Crop Protection Conference, 83-92. 1997.

11. Duke, S. O., Dayan, F. E., Hernández, A., Duke, M. V. and Abbas, H. K.  Natural products as leads for new herbicide modes of action. Proceedings of the Brighton Crop Protection Conference, 579-586.  1997.

1998
12. Dayan, F. E., Duke, S. O., Faibis, V., Jacobs, J. M., and Jacobs, N. J.  Horseradish peroxidase-dependent oxidation of deuteroporphyrin IX into chlorins. Archives of Biochemistry and Biophysics, 351, 27-34.  1998.

13. Reddy, K. N., Dayan, F. E., and Duke, S. O.  QSAR analysis of protoporphyrinogen oxidase inhibitors in Comparative QSAR (James Devillers, ed).  Taylor and Francis.  197-233.  1998.

14. Dayan, F. E., Armstrong, B. M., Weete, J. D.  Inhibitory activity of sulfentrazone and its metabolic derivatives on soybean (Glycine max) protoporphyrinogen oxidase, Journal of Agricultural and Food Chemistry, 46, 2024-2029.  1998.

15. Duke, S. O., Dayan, F. E., and Rimando, A. M.  Natural products as tools for weed management. Proceedings of the Japanese Weed Science Society (Suppl.) pp. 1-11.  1998.

16. Rimando, A. M., Dayan, F. E., Czarnota, M. A., Weston, L. A., and Duke, S. O.  A new photosystem II electron transfer inhibitor from Sorghum bicolor (L.).  Journal of Natural Products, 61, 927-930.  1998.

1999
17. Dayan, F. E., Reddy, K. N., and Duke, S. O.  Structure-activity relationships of diphenyl ethers and other oxygen-bridged protoporphyrinogen oxidase inhibitors in Peroxidizing Herbicides (Böger, P. and Wakabayashi, eds.).  Springer-Verlag, Berlin, pp. 141-161.  1999.

18. Dayan, F. E., Hernández, A., Allen, S. N., Moraes, R. M., J. A. Vroman, Avery, M. A., and Duke, S. O.  Comparative phytotoxicity of artemisinin and several sesquiterpene analogues.  Phytochemistry, 50, 607-614.  1999.

19. Duke, S. O. and Dayan, F. E.  Probing plastid functions with phytotoxins that target specific sites.  RIKEN Review, 21, 9-10.  1999.

20. Streibig, J., Dayan, F. E., Rimando, A. M., and Duke, S. O.  Joint action of natural and synthetic photosystem II inhibitors.  Pesticide Science, 55, 137-146.  1999.

21. Dayan, F. E and Tellez, M. R.  Phytotoxicity of tarbush (Flourensia cernua D.C.) leaf extracts, Allelopathy Journal, 6, 1-12. 1999.

22. Dayan, F. E., Rimando, A. M., Duke, S. O., and Jacobs, N. J.  Thiol-dependent degradation of protoporphyrin IX by plant peroxidases.  FEBS Letters, 444, 227-230.  1999. 

23. Jacobs, N. J., Kruszyna, H., Hier, J., Dayan, F. E., Duke, S. O., Pont, F., and Montforts, F.-P.  Glutathione-dependent oxidative modification of protoporphyrin and other dicarboxylic porphyrins by mammalian and plant peroxidases.  Biochemical and Biophysical Research Communications, 259, 195-200. 1999.

24. Rimando. A. M., Dayan, F. E., Mikell, J. R., and Moraes, R. M.  Phytotoxic lignans of Leucophyllum frutescens.  Journal of Natural Toxins, 7, 1-5.  1999.

25. Dayan, F. E., Watson, S. B., Galindo, J.C.G., Hernandez, A., Dou, J., McChesney, J. D. and Duke, S.O.  Phytotoxicity of quassinoids: Physiological responses and structural requirements.  Pesticide Biochemistry and Physiology, 65, 15-24. 1999.

26. Galindo, J.C.G., Hernández, A., Dayan, F. E., Tellez, M. R., Macías, F. A., Paul, R. N., and Duke, S. O.  Dehydrozaluzanin C, A natural sesquiterpenolide, causes rapid plasma membrane leakage.  Phytochemistry, 52, 805-813. 1999.

27. Dayan, F. E., Romagni, J. G., Tellez, M. R., Rimando, A. M., and Duke, S. O. Managing weeds with natural products.  Pesticide Outlook, 5, 185-188. 1999.

2000
28. Romagni, J. G., Allen, S. N., and Dayan, F. E.  Allelopathic effects of volatile cineoles on two weedy plant species.  Journal of Chemical Ecology, 26, 303-313. 2000.

29. Duke, S. O., Dayan, F. E., Romagni, J. G., and Rimando, A. M.  Natural products as sources of herbicides: current status and future trends.  Weed Research, 40, 99-111. 2000.

30. Schrader, K. K., Dayan, F. E., Allen, S. N., de Regt, M. Q., Tucker, C. S., and Paul, R. N. Jr. 9,10-Anthraquinone reduces the photosynthetic efficiency of Oscillatoria perornata and modifies cellular inclusions.  International Journal of Plant Science, 161, 265-270. 2000.

31. Dayan, F. E. and Allen, S. N. Predicting the activity of the natural phytotoxic diphenyl ether cyperine using comparative molecular field analysis.  Pest Management Science, 56, 717-722. 2000. 

32. Romagni, J. G. and Dayan, F. E. Measuring asparagine synthetase activity in crude plant extracts.  Journal of Agricultural and Food Chemistry, 48, 1692-1696. 2000.

33. Duke, S. O., Dayan, F. E., and Rimando, A. M. Natural products and herbicide discovery in Herbicides and their Mechanisms of Action (Cobb, A. H. and Kirkwook, R. C, eds).  Sheffield Academic Press, Sheffield, UK pp. 105-133. 2000.

34. Dayan, F. E., Romagni, J. G., and Duke, S. O.  Investigating the mode of action of natural phytotoxins.  Journal of Chemical Ecology, 26, 2079-2094. 2000.

35. Dayan, F. E., Vincent, A., Romagni, J. G., Allen, S. N., Duke, S. O., Duke, M. V., Bowling, J. J.,and Zjawiony, J. K.  Amino- and urea-substituted thiazoles inhibit photosynthetic electron transfer.  Journal of Agricultural and Food Chemistry, 48, 3689-3693, 2000.

36. Romagni, J. G., Duke, S. O., and Dayan, F. E. Inhibition of plant asparagine synthetase by monoterpene cineoles.  Plant Physiology, 123, 725-732. 2000.

37. Duke, S. O., Rimando, A. M., Dayan, F. E., Canel, C., Wedge, D. E., Tellez, M. R., Schrader, K. K., Weston, L. A., Smillie, T. J., Paul, R. N. and Duke. M. V.  Strategies for the discovery of bioactive phytochemicals in Phytochemicals as Bioactive Agents. W.R. Bidlack, S.T. Omaye, M.S. Meskin, and D.K.W. Topham, eds., Technomic Publishing Co., Lancaster, PA, pp. 1-20. 2000.

38. Grey, T. L., Walker, R. H., Wehtje, G. R., Adams, J., Dayan, F. E., Weete, J. D., Hancock, H. G., and Kwon, O.  Behavior of sulfentrazone in ionic exchange resins, electrophoresis gels, and cation-saturated soils.  Weed Science, 48, 239-247.  2000.

39. Tellez, M. R., Dayan, F. E., Schrader, K., Wedge, D. E., Duke, S. O. Composition and some biological activities of the essential oil of Callicarpa americana (L.).  Journal of Agricultural and Food Chemistry, 48, 3008-3012. 2000.

40.  Canel, C., Moraes, R. M., Dayan, F. E., and Ferreira, D.  Podophyllotoxin.  Phytochemistry, 54, 115-120. 2000.

41. Duke, S. O., Romagni, J. G., and Dayan. F. E., Natural products as sources for new mechanisms of herbicidal action. Crop Protection 19, 583-589. 2000.

42. Romagni, J. G., Meazza, G, Nanayakkara, N. P. D., and Dayan, F. E., The phytotoxic lichen metabolite, usnic acid, is a potent inhibitor of plant p-hydroxyphenylpyruvate dioxygenase.  FEBS Letters, 480, 301-305, 2000.

43. Vincent, A., Dayan, F. E., Maas, J. L., and Wedge, D. E.  Detection and isolation of antifungal compounds in strawberry inhibitory to Colletotrichum fragariae.  Advances in Strawberry Research, 18, 28-36, 2000.

44. Canel, C., Dayan, F. E., Moraes, R. M., and Burandt, C. L. Enhanced yield of podophyllotoxin from natural products through in situ conversion methods.  US patent 6,143,304.  pp. 4. 2000.

2001
45. Canel, C., Dayan, F. E., Ganzera, M., Khan, I., Rimando, A. M., Burandt, C. L. Jr., and Moraes, R. M.  High yields of podophyllotoxin from leaves of Podophyllum peltatum by in situ conversion of podophyllotoxin-4-O-?-D-glucopyranoside.  Planta Medica, 67, 97-99. 2001.

46. Rimando, A. M., Olofsdotter, M., Dayan, F. E., and Duke, S. O., Searching for rice allelochemicals: an example of bioassay-guided isolation.  Agronomy Journal, 93, 16-20.  2001.

47. Dayan, F. E., Meazza, G., Bettarini, F., Signorini, E., Piccardi, P., Romagni, J. G., and Duke, S. O. Synthesis, Herbicidal activity and mode of action of IR 5790.  Journal of Agricultural and Food Chemistry, 49, 2302-2307. 2001.

48. Scheffler, B. E., Duke, S. O., Dayan, F. E., and Ota, E.  Crop allelopathy: Enhancement through biotechnology in Recent Advances in Phytochemistry. Vol. 35 Regulation of phytochemicals by molecular techniques (Romeo, J. T., Saunders, J. A., Matthews, B. F. Eds), pp. 257-274. 2001.

49. Duke, S. O., Scheffler, B. E., Dayan, F. E., Weston, L. A., and E. Ota. Strategies for using transgenes to produce allelopathic crops, Weed Technology, 15, 826-834. 2001.

50. Czarnota, M. A., Paul, R. N., Dayan, F. E., Nimbal, C. I., and Weston, L. A.  Mode of action, localization of production, chemical nature, and activity of sorgoleone: A potent PSII inhibitor in Sorghum spp. root exudates, Weed Technology, 15, 813-825. 2001.

51. Dayan F. E., Romagni, J., and Duke, S. O.  Protoporphyrinogen oxidase inhibitors in Handbook of Pesticide Toxicology, 2nd Edition (Krieger, R., Doull, J., Ecobichon, D., Gammon, D., Hodgson, E., Reiter, L., and Ross, J., Eds). Vol 2, Chapter 68,  Academic Press, San Diego, CA., pp. 1529-1542.  2001.

52. Kobaisy, M., Tellez, M. R., Webber, C. L., Dayan, F. E., Schrader, K. K., and Wedge, D. E. Phytotoxic and fungitoxic activities of the essential oil of kenaf (Hibiscus cannabinus L.) leaves and its composition.  Journal of Agricultural and Food Chemistry 49, 3768-3771. 2001.

53. Duke, S. O. and Dayan, F. E. Classification and mode of action of herbicides in Uso de Herbicidas en la Agricultura del Siglo XXI,  pp. 31-44.  2001.

54. Duke, S. O., Baerson, S. R., Dayan, F. E., Kagan, I. A., Michel, A., and Scheffler, B. E. Biocontrol of Weeds without the Biocontrol Agents in Enhancing Biocontrol Agents and Handling Risks (Vurro, M., Gressel, J., Butt, T., Harman, G. E., Pilgeram, A., St. Leger, R. J., and Nuss, D. L., eds). I.O.S. Press, Inc., Amsterdam, pp. 96-105. 2001.

55. Dayan, F. E. and Romagni, J. G.  Lichens as a potential source of pesticides.   Pesticide Outlook, 12, 229-232. 2001.

2002
56. Dayan, F. E., Natural pesticides in Encyclopedia of Pest Management (D. Pimentel, Ed), Marcel Dekker, Inc., New York, NY, 521-525. 2002.

57. Moraes, R. M., Dayan, F. E., and Canel, C.  The lignans of podophyllum in Bioactive Natural Products Vol. 26 Part G., Atta Ur Rahman (ed), Elsevier, Amsterdam. 149-182. 2002.

58. Tellez, M. R., Duke, S. O., Dayan, F. E., Romagni, J. G., Schrader, K. E.  Terpenoid-based defense in plants and other organisms in Lipid Biotechnology, Kuo, T. M. and Gardner, H. W. Eds.  Marcel Dekker, Inc. New York, NY. 319-355. 2002.

59. Duke, S. O., Scheffler, B. E.,  Dayan, F. E., and Dyer, W. E. Genetic engineering crops for improved weed management traits in Crop Biotechnology, K. Rajasekaran, T. J. Jacks and J. W. Finley Eds. American Chemical Society Symposium Series, 829, 52-66.  2002.

60. Romagni, J. G. and Dayan, F. E.  Structural diversity of lichen metabolites and their potential use in Advances in Microbial Toxin Research and Its Biotechnological Exploitation (Upadhyay, R. K. Ed), Kluwer Academic/Plenum Publisher, New York, NY. 151-169. 2002.

61. Oliva, A., Moraes, R. M., Watson, S. B., Duke, S. O., and Dayan, F. E. Aryltetralin lignans inhibit plant growth by affecting the formation of mitotic microtubular organizing centers.  Pesticide Biochemistry and Physiology, 72, 45-54 . 2002.

62. Meazza, G., Scheffler, B. E., Tellez, M. R., Rimando, A. M., Nanayakkara, N. P. D., Khan, I. A., Abourashed, E. A., Romagni, J. G., Duke, S. O, and Dayan, F. E., The inhibitory activity of natural products on plant p-hydroxyphenylpyruvate dioxygenase, Phytochemistry, 59, 281-288. 2002.

63. Dayan, F.E., Rimando, A. M., Tellez, M. R., Scheffler, B. E.,Roy, T., Abbas, H. K., and Duke, S. O.  Bioactivation of the fungal phytotoxin 2,5-anhydro-D-glucitol by glycolytic enzymes is an essential component of its mechanism of action.  Zeitschrift für Naturforschung, C, 57c, 645-653. 2002.

64. Duke, S. O., Dayan, F. E., Rimando, A. M., Schrader, K. K., Aliotta, G., Oliva, A., Romagni, J. G. Chemicals from nature for weed management. Weed Science, 50, 138-151. 2002.

65. Dayan, F.E. Octan-1-ol / water partition coefficients of p-benzo- and p-naphthoquinones corrected for pH effect.  Journal of Chemical Research, 10, 518-519. 2002.

66. Futagawa, M., Wedge, D. E., and Dayan, F. E.  Physiological factors influencing the antifungal activity of zopfiellin.  Pesticide Biochemistry and Physiology 73, 87-93.  2002.

67. Romagni, J. G., Rosell, R. C., Nanayakkara, D., and Dayan, F. E.  Ecophysiology and potential modes of action for selected lichen secondary metabolites in Allelopathy: From Molecules to Ecosystems (Reigosa, M. J. and Pedrol, N., Eds), Science Publishers, Inc., Enfield, NH.  113-127. 2002.

68. Duke, S. O., Rimando, A. M., Scheffler, B. E., and Dayan, F. E.  Strategies for research in applied aspects of allelopathy in Allelopathy: From Molecules to Ecosystems (Reigosa, M. J. and Pedrol, N., Eds), Science Publishers, Inc., Enfield, NH.  139-152. 2002.

69. Duke, S. O., Scheffler, B. E., and Dayan, F. E.  Allelochemicals as herbicides in Allelopathy: From Molecules to Ecosystems (Reigosa, M. J. and Pedrol, N., Eds), Science Publishers, Inc., Enfield, NH.  183-195. 2002.

70. Kobaisy, M., Tellez, M. R., Dayan, F. E., Duke, S. O.  Phytotoxicity and volatile constituents from leaves of Callicarpa japonica Thunb.    Phytochemistry   61, 37-40. 2002.

71. Tellez, M. R., Khan, I. A., Kobaisy, M., Schrader, K. K., Dayan, F. E., Osbrink, W.  Composition of the essential oil of Lepidium meyenii (Walp.).    Phytochemistry  61,  149-155. 2002.

2003
72. Dayan, F. E., Romagni, J. G., and Duke, S. O., Herbicides: Cinmethylin in Encyclopedia of Agrochemicals (J. R. Plimmer, D. W. Gammon, N. N. Ragsdale, and T. Roberts, Eds), John Wiley & Sons, New York, NY, Vol. 2, pp. 754-757. 2003.

73. Dayan, F. E. and Duke, S. O., Herbicides: Protoporphyrinogen oxidase inhibitors in Encyclopedia of Agrochemicals (J. R. Plimmer, D. W. Gammon, N. N. Ragsdale, and T. Roberts, Eds), John Wiley & Sons, New York, NY, Vol. 2, pp. 850-863.  2003.

74. Dayan, F. E. and Duke, S. O. Herbicides: Carotenoid biosynthesis inhibitors in Encyclopedia of Agrochemicals (J. R. Plimmer, D. W. Gammon, N. N. Ragsdale, and T. Roberts, Eds), John Wiley & Sons, New York, NY, Vol. 2, pp. 744-749. 2003.

75. Rimando, A. M., Dayan, F. E. and Streibig, J. C. PSII inhibitory activity of resorcinolic lipids from Sorghum bicolor. Journal of Natural Products.  66, 42-45.  2003.

76. Duke, S. O., Dayan, F. E., Baerson, S. R., Romagni, J. G., Agarwal, A. and Oliva, A. Natural phytotoxins with potential for development in weed management strategies. In Chemistry of Crop Protection, G. Ramos and G. Voss, eds., Wiley-VCH Verlag, Weinheim, Germany, pp. 143-154. 2003.

77. Dayan, F. E., Kuhajek, J., Canel, C., Watson, S. B., and Moraes, R. M., Podophyllum peltatum possesses a ?-glucosidase with high substrate specificity for the aryltetralin lignan podophyllotoxin, Biochimica et Biophysica Acta, Proteins and Proteomics, 1646, 157-163. 2003.

78. Meazza, G., Dayan, F. E., and Wedge D. E. Activity of quinones on Colletotrichum species, Journal of Agricultural and Food Chemistry, 51, 3824-3828. 2003.

79. Dayan, F. E., Kagan, I. A., and Rimando, A. M., Elucidation of the biosynthetic pathway of the allelochemical sorgoleone using retrobiosynthetic NMR analysis.  Journal of Biological Chemistry, 278, 28607-28611.

80. Duke, S. O., Baerson,S. R., Dayan, F. E., Rimando, A. M., Scheffler, B. E., Tellez, M. R., Wedge, K. K. Schrader, D. E.,  Akey, D. H., Arthur, F. H., De Lucca, A. J., Gibson, D. M., Harrison, H. F., Jr., Peterson, J. K., Gealy, D. R.,  Tworkoski, T., Wilson, C. L., and Morris, J. B. United States Department of Agriculture-Agricultural Research Service research on natural products for pest management, Pest Management Science, 59, 708-717. 2003.