Sharifa Love |
Name: Sharifa Love
School: Tougaloo College Major: Chemistry Mentor: Dr. Randy Wadkins Expected Graduation Date: May 2008 Organizations & Honors:
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ABSTRACT
Introduction of a Mutation in a Loop of Carboxylesterase
| Carboxylesterases (CEs) are the enzymes responsible for the activation of pro-drugs and the detoxification of xenobiotics. They metabolize many different types of substrates such as carboxyl esters, carbamates, thioesters, and amides. We can infer from this that CEs have a large diversity of substrates. By introducing a single site mutation to this enzyme, we hope to create significant structural change in the enzyme as compared to the wild type CE. |