The Chamber (1996) is a film about Sam Cayhall (Gene Hackman): a Mississippi inmate on death row for the racist murder of two young Jewish boys. Chris O'Donnell plays Cayhall's grandson who appeals the decision to send his grandfather to the gas chamber. Faye Dunaway also appears in the movie as Sam Cayhall's traumatized daughter, Lee Cayhall Bowen. In an Entertainment Weekly interview, Grisham described the movie as "dreadful" and that "Gene Hackman was the only good thing in it."

Other film adaptations of Grisham's books include:
The Rainmaker (1997), The Gingerbread Man (1988), A Painted House (2003), Runaway Jury (2003), The Street Lawyer (2003), Mickey (2004), Christmas with the Kranks (2004).